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Table 6 Expression levels of host genes containing miRNAs deregulated in ER+ compared to ER− breast tumors in the validation series

From: MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers?

  

Breast tissue

ER+/ER−

miRNA

Host gene

Normal (n = 8)

ER+ (n = 85)

ER− (n = 68)

FC

p-value

miR-26a1

CTDSPL

1.0

0.95

0.42

2.26

<0.0001

  

(0.49-2.20)

(0.21-19.6)

(0.03-7.64)

  

miR-342-5p

EVL

1.0

3.36

0.54

6.17

<0.0001

  

(0.89-1.42)

(0.16-26.9)

(0.08-2.77)

  

miR-30e

NFYC

1.0

1.00

0.90

1.11

0.0143

  

(0.85-1.42)

(0.06-2.91)

(0.45-2.46)

  

miR-30c2

OGFRL1

1.0

0.67

0.44

1.51

0.0002

  

(0.69-1.29)

(0.03-2.20)

(0.08-2.04)

  

miR-26b

CTDSP1

1.0

0.93

0.67

1.39

<0.0001

  

(0.66-1.56)

(0.20-3.85)

(0.25-3.11)

  

miR-1244

PTMAP2

1.0

1.41

1.89

−1.34

0.0002

  

(0.53-2.04)

(0.00-6.10)

(0.85-12.4)

  
  1. Results in ER+ and ER− breast tumors are expressed as the median (range) of level relative to normal breast tissues. For each comparison, we report the fold-change (FC) and the p-value associated to Mann-Whitney’s test (ns for not significant)
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BMC Cancer

ISSN: 1471-2407

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