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Table 5 Expression levels of 4 genes required for miRNA biogenesis in breast tissues

From: MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers?

 

Breast tissue

ER+/ER

ER+/Normal

ER/Normal

Gene

Normal (n = 8)

ER+ (n = 85)

ER (n = 68)

FC

p-value

FC

p-value

FC

p-value

DICER1

1.0

0.92

0.50

1.85

<0.0001

−1.09

ns

−2.00

0.0004

 

(0.79-1.36)

(0.05-3.18)

(0.10-1.94)

      

DROSHA

1.0

1.27

0.77

1.65

<0.0001

1.27

ns

−1.30

0.0486

 

(0.77-1.56)

(0.08-4.91)

(0.09-6.37)

      

DGCR8

1.0

1.05

0.72

1.46

<0.0001

1.05

ns

−1.39

0.0506

 

(0.78-1.56)

(0.19-4.77)

(0.13-3.44)

      

AGO2

1.0

0.80

1.10

−1.37

0.0433

−1.25

ns

1.10

ns

 

(0.56-1.10)

(0.17-3.74)

(0.08-4.74)

      
  1. Results in ER+ and ER breast tumors are expressed as the median (range) of level relative to normal breast tissues. For each comparison, we report the fold-change (FC) and the p-value associated to Mann-Whitney’s test (ns for not significant)