Author, pub date and location | Trial name and acronym Eligibility criteria | Type of intervention | Trial duration and number of participants recruited | Run in phase | ITT analysis | Characteristics of participants | Summary of trial findings as reported in publication |
---|---|---|---|---|---|---|---|
Smith Warner 2000 31 | Minnesota cancer prevention research unit diet intervention trial–Minnesota CPRU | Diet | 12 months n = 100 | No | Yes | Mean age 59 years | Individuals at high risk for development of colorectal cancer can successfully increase F&V intake and maintain that increase over a year period. |
USA | 30-74 years with a diagnosis of colorectal polyps in preceding 5Â years, no medical conditions or chronic disease. | Â | Â | Â | Â | 71Â % male, 99Â % Caucasian, mean number of years in education was 15 | |
Lanza 2001 32 | Polyp Prevention Trial–PP trial | Diet | 4 years n = 1037 | Yes, 4 day food record and frequency survey | Yes | Mean age 61 years | Free-living individuals can alter their eating patterns in a significant way given appropriate support |
USA | ≥35 years having removal of ≥ 1 colorectal adenomas removed within past 6 months, no history of colorectal cancer |  |  |  |  | 66 % male, 12 % minority race, 65 % higher than high school education | |
Emmons 2005 33 | Project PREVENT | Diet and physical activity | 8 months n = 591 | No | Yes | 46 % aged 40–59 years and 54 % aged over 60 years | PREVENT was effective in helping adenoma patients to change and reduce behavioral risk factors and behavioral change is possible in this population |
USA | 40-65 years with a adenomatous colon polyp removed within 4Â weeks of recruitment, no history of colorectal cancer | Â | Â | Â | Â | 56Â % male,83Â % white, non Hispanic, 74Â % higher than high school education | |
Caswell 2009 34 | Bowel Health to Better Health–BHBH | Diet and physical activity | 12 weeks n = 41 | No | Not explicit | Mean age 62 years | Population is responsive to minimal contact intervention to promote positive change in diet |
UK | 50-74 years | Â | Â | Â | Â | 71Â % male, 100Â % Caucasian | |
 | ≥1 colorectal adenoma, no evidence of colorectal carcinoma or metaplastic or hyperplastic non-adenomatous polyps |  |  |  |  | Index of multiple deprivation low 20 %, medium 40 %, high 40 % | |
Anderson 2014 UK 35 | BeWEL, 50–74 years, undergone polypectomy for adenoma, able to undertake physical activity | Diet and physical activity | 12 months n = 163 | No | Yes | Mean age 63.5 years, 74 % male, 100 % white, 86 % equal to higher than secondary school education | Significant weight loss can be achieved by a diet and physical activity intervention initiated within a national colorectal cancer screening programme |