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Table 1 Correlation of LVD with clinicopathological parameters and survival

From: The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis

Factors (N) I-LVD P-LVD
   mean ± SD P mean ± SD P
Age <60 (33) 12.60 ± 5.32 N.S. 10.52 ± 3.22 N.S.
  >60 (33) 11.99 ± 3.15   11.53 ± 3.99  
Sex Male (47) 12.31 ± 4.79 N.S. 11.06 ± 3.91 N.S.
  Female (19) 12.24 ± 3.11   10.88 ± 2.83  
Extent of resection Total gastrectomy (16) 13.78 ± 5.62 N.S. 12.36 ± 5.30 N.S.
  Subtotal gastrectomy (50) 11.82 ± 3.81   10.59 ± 2.87  
Tumor location Upper 1/3 (12) 12.01 ± 3.30 N.S. 11.74 ± 5.40 N.S.
  Middle 1/3 (21) 13.49 ± 5.18   11.26 ± 3.63  
  Lower 1/3 (32) 12.33 ± 4.37   10.63 ± 2.92  
Tumor size <5cm (36) 12.20 ± 4.98 N.S. 10.55 ± 3.61 N.S.
  >5cm (30) 12.40 ± 3.53   11.56 ± 3.62  
Lauren classification Intestinal type (31) 11.20 ± 3.06 0.048* 10.10 ± 2.74 N.S.
  Diffuse type (35) 13.26 ± 5.09   11.55 ± 4.23  
Differentiation Differentiated (31) 11.03 ± 2.80 0.021* 10.49 ± 2.74 N.S.
  Undifferentiated (35) 13.41 ± 5.15   11.47 ± 4.25  
Tumor stage (AJCC 7th ed.) T1 (18) 10.22 ± 3.53 0.024* 9.87 ± 3.55 N.S.
  T2 (11)) 12.95 ± 4.09   11.70 ± 3.64  
  T3 (26) 12.23 ± 3.95   11.05 ± 3.74  
  T4 (11) 15.16 ± 5.37   12.18 ± 3.37  
LVI Negative (37) 10.96 ± 3.80 0.004* 10.18 ± 3.71 0.028*
  Positive (29) 13.99 ± 4.48   12.12 ± 3.28  
Node stage (AJCC 7th ed.) N0 (36) 11.26 ± 3.84 0.052 10.00 ± 2.77 0.040*
  N1 (3) 3.34 ± 2.20   10.25 ± 0.55  
  N2 (7) 13.51 ± 3.79   12.38 ± 1.84  
  N3 (20) 14.16 ± 5.00   12.67 ± 4.38  
Tumor node metastasis stage (AJCC 7th ed.) I (20) 10.45 ± 3.93 0.029* 9.81 ± 3.02 0.061
  II (30) 12.27 ± 3.58   10.88 ± 3.18  
  III (18) 14.17 ± 5.14   12.56 ± 4.48  
DFS (month) LVD-Low (38) 57.82 ± 3.07 N.S. 59.31 ± 2.77 0.037*
  LVD-High (28) 51.45 ± 4.84   51.21 ± 4.81  
OS (month) LVD-Low (38) 61.70 ± 2.62 0.031* 60.06 ± 2.70 0.088
  LVD-High (28) 52.60 ± 4.44   55.96 ± 4.14  
  1. LVI, lympho-vascular invasion; DFS, disease free survival; OS, overall survival
  2. *, P <0.05; N.S., not significant; data are expressed as means ± SD