Fig. 6

Differential activity of PPARα-wt and PPARα-tr on the WNT/β-catenin and NF-kB promoter binding elements. a Quantitative luciferase reporter gene assays with the constructs containing 4xTCF/LEF response elements were performed in human HuH7 cells 48 h after indicated treatments and in total 72 h after the transfection with the indicated constructs. The bars represent the fold induction of luciferase activity normalized to the control state without any treatment (indicated with the dotted line). Error bars indicate standard deviation between three independent experiments. * indicates siginificance p < 0.05. b. Quantitative luciferase reporter gene assays with the constructs containing 3xNF-kB response elements were performed in human HuH7 cells 48 h after indicated treatments and in total 72 h after the transfection with the indicated constructs. The bars represent the fold induction of luciferase activity normalized to the control state without any treatment (indicated with the dotted line). Error bars indicate standard deviation between three independent experiments. * indicates siginificance p < 0.05