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Fig. 3 | BMC Cancer

Fig. 3

From: Estrogen receptor α enhances the transcriptional activity of ETS-1 and promotes the proliferation, migration and invasion of neuroblastoma cell in a ligand dependent manner

Fig. 3

ERα but not the HGF/c-Met mediated the enhancement of ETS-1 activity induced by estrogen. a,b Cells were treated with 100nM E2 (the ECmax concentration of estrogen). The SH-SY5Y cells were stably transfected with empty vector (a), ERα vectors (a), control siRNA (b,d), ERα siRNA (b), ETS-1 vector (d) or ETS-1 siRNA (d); whereas MDA-MB-231 cells were stably transfected with empty vector (c) or ERα vectors (c). Then, cells which were co-transfected with EBS-Luc reporters and harvested for the Luciferase analysis. The expression of ERα and ETS-1 were determined by immunoblots, and the results were showed at the panels at the bottom of the figure. The values are the mean ± SD from three independent experiments. * P < 0.05

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