Table 4 Cox regression analysis for overall survival (OS), progression-free survival (PFS), and AML transformation^a

Age (years)

0.987–1.073

0.174

0.996–1.084

0.074

1.007

0.952–1.064

0.819

Sex (male vs. female)

0.298–1.695

0.442

0.388–1.999

0.761

0.823

0.266–2.553

0.737

IPSS-R total score

1.263–2.115

<0.0001

1.214–1.969

<0.0001

1.699

1.200–2.405

0.003

SF3B1^b (mut vs. WT)

0.572–12.397

0.212

0.193–12.145

0.686

U2AF1 (mut vs. WT)

0.365–7.436

0.516

1.655–14.157

0.004

1.252

0.149–10.494

0.836

SRSF2 (mut vs. WT)

0.270–5.485

0.799

1.604–11.952

0.004

2.672

0.697–10.245

0.152