Characteristics | SF3B1wt (n = 120, 93.0 %) | SF3B1mut (n = 9, 7.0 %) | P | U2AF1wt (n = 119, 92.2 %) | U2AF1mut (n = 10, 7.8 %) | P | SRSF2wt (n = 116, 89.9 %) | SRSF2mut (n = 13, 10.1 %) | P |
---|---|---|---|---|---|---|---|---|---|
Age (years)a | 63.4 ± 11.9 | 67.9 ± 19.1 | 0.295 | 63.6 ± 12.5 | 63.8 ± 11.8 | 0.975 | 62.8 ± 12.7 | 71.5 ± 5.5 | 0.000 |
Sex | 0.730 | 0.183 | 0.381 | ||||||
Male, n (%) | 67 (55.8) | 4 (44.4) | 63 (52.9) | 8 (80.0) | 62 (53.4) | 9 (70.2) | |||
Female, n (%) | 53 (44.2) | 5 (55.6) | 56 (47.1) | 2 (20.0) | 54 (46.6) | 4 (30.8) | |||
Blood countsa | |||||||||
WBC (× 103/μl) | 5.6 ± 14.3 | 3.7 ± 1.8 | 0.700 | 5.5 ± 14.4 | 5.1 ± 4.6 | 0.935 | 5.6 ± 14.6 | 4.2 ± 2.7 | 0.734 |
Neutrophil (× 103/μl) | 3.4 ± 12.0 | 1.5 ± 1.3 | 0.650 | 3.2 ± 12.1 | 3.4 ± 3.9 | 0.960 | 3.4 ± 12.3 | 1.9 ± 1.9 | 0.672 |
Hemoglobin (g/dl) | 9.7 ± 2.2 | 9.2 ± 2.3 | 0.556 | 9.7 ± 2.2 | 8.4 ± 2.0 | 0.063 | 9.7 ± 2.3 | 9.4 ± 1.8 | 0.657 |
Platelet (× 103/μl) | 95 ± 91 | 168 ± 151 | 0.183 | 100 ± 98 | 92 ± 87 | 0.806 | 100 ± 100 | 91 ± 67 | 0.734 |
Bone marrow blasts (%) | 5.3 ± 5.3 | 3.8 ± 5.0 | 0.398 | 5.0 ± 5.2 | 7.7 ± 6.2 | 0.123 | 5.2 ± 5.4 | 5.6 ± 4.3 | 0.783 |
WHO subtype, n (%) | 0.303 | 0.516 | 0.094 | ||||||
RCUD | 18 (15.0) | 1 (11.1) | 19 (16.0) | 0 (0.0) | 18 (15.5) | 1 (7.7) | |||
RCMD | 51 (42.5) | 5 (55.6) | 52 (43.7) | 4 (40.0) | 50 (43.1) | 6 (46.2) | |||
RAEB-1 | 15 (12.5) | 1 (11.1) | 13 (10.9) | 3 (30.0) | 11 (9.5) | 5 (38.5) | |||
RAEB-2 | 29 (24.2) | 1 (11.1) | 27 (22.7) | 3 (30.0) | 29 (25.0) | 1 (7.7) | |||
MDS-U | 1(0.8) | 0 (0.0) | 1 (0.8) | 0 (0.0) | 1 (0.9) | 0 (0.0) | |||
MDS associated with isolated del(5q) | 1 (0.8) | 1 (11.1) | 2 (1.7) | 0 (0.0) | 2 (1.7) | 0 (0.0) | |||
Hypoplastic MDS | 5 (4.2) | 0 (0.0) | 5 (4.2) | 0 (0.0) | 5 (4.3) | 0 (0.0) | |||
Karyotype, n (%) | 0.013 | 0.022 | 0.048 | ||||||
Normal | 87 (72.5) | 6 (66.7) | 87 (73.1) | 6 (60.0) | 86 (74.1) | 7 (53.8) | |||
-Y only | 3 (2.5) | 0 (0.0) | 3 (2.5) | 0 (0.0) | 3 (2.6) | 0 (0.0) | |||
−5 or del(5q) | 2 (1.7) | 1 (11.1) | 3 (2.5) | 0 (0.0) | 3 (2.6) | 0 (0.0) | |||
del(11q) | 1 (0.8) | 0 (0.0) | 1 (0.9) | 0 (0.0) | 0 (0.0) | 1 (7.7) | |||
del(20q) | 0 (0.0) | 1 (11.1) | 1 (0.9) | 0 (0.0) | 1 (0.9) | 0 (0.0) | |||
−7 | 1 (0.8) | 0 (0.0) | 0 (0.0) | 1(10.0) | 1 (0.9) | 0 (0.0) | |||
Complex (≥3) | 11 (9.2) | 0 (0.0) | 11 (9.2) | 0 (0.0) | 8 (6.9) | 3 (23.1) | |||
Other | 15(12.5) | 1 (11.1) | 13 (10.9) | 3 (30.0) | 14 (12.0) | 2 (15.4) | |||
IPSS-R risk classification, n (%) | 0.133 | 0.270 | 0.505 | ||||||
Very low | 14 (11.8) | 1 (11.1) | 15 (12.6) | 0 (0.0) | 14 (12.1) | 1 (7.7) | |||
Low | 25 (20.8) | 5 (55.6) | 29 (24.4) | 1 (10.0) | 29 (25.0) | 1 (7.7) | |||
Intermediate | 40 (33.3) | 2 (22.2) | 39 (32.8) | 3 (30.0) | 36 (31.0) | 6 (46.2) | |||
High | 31 (25.8) | 0 (0.0) | 26 (21.8) | 5 (50.0) | 28 (24.1) | 3 (23.1) | |||
Very high | 10 (8.3) | 1 (11.1) | 10 (8.4) | 1 (10.0) | 9 (7.8) | 2 (15.3) |