Fig. 7

Independent tests on CCLE model for AZD6244, Erlotinib and PD-0325901. Boxplot and ROC curve (the bottom curve indicates drug response, measured as the area over the dose–response curve, i.e., activity area) have been built to evaluate the svm model. (a) For drug AZD6244, p-value by t test is 3.316e-12 and area under the curve is 0.668. (b) For drug Erlotinib, p-value by T test is 0.01885 and area under the curve is 0.57. (c) For drug PD-0325901, p-value by t test is 5.851e-14 and area under the curve is 0.70