Fig. 6From: Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cellsVCP inhibition results in nuclear Lys48 ubiquitin protein accumulation and DNA damage. Cells were cultured for 12 h with or without 3 μM EER-1. Co-immunolabelling was performed for Lys48 ubiquitin and γH2AFX for treated (right panels) and untreated cells (left panels). A negative control was performed without the primary antibody (not shown)Back to article page