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Table 4 Main published studies about patient with recurrent high grade glioma (III–IV) treated with chemotherapy alone

From: Multimodality therapy approaches, local and systemic treatment, compared with chemotherapy alone in recurrent glioblastoma

Authors Study N. PTS Treatment PFS (months) PFS 6 % OS (months)
Van Den Bent et al. [15] Phase II rand 108 BCNU or TMZ vs Erlotinib 2.4 24.1 7.3
54 1.8 11.4 7.7
Brandes et al. [33] Phase II 40 BCNU NA 17.5 7.5
Addeo et al. [18] Phase II 40 Fotemustine 6.7 61 11.1
Brada et al. [14] Phase II 126 TMZ 2.1 18 5.4
Wich et al. [29] Phase II 64 TMZ 1wk on/1 wk off 5.5 43.8 NA
Brada et al. [21] Phase II rand 87 TMZ 5 days 5 NA 8.5
81 TMZ 21 days 4.2 6.6
162 PCV 3.6 6.7
  1. TMZ temozolomide, NA not available, mos months, PFS6 progression free at 6 months