Multimodality therapy approaches, local and systemic treatment, compared with chemotherapy alone in recurrent glioblastoma

Table 4 Main published studies about patient with recurrent high grade glioma (III–IV) treated with chemotherapy alone

Authors	Study	N. PTS	Treatment	PFS (months)	PFS 6 %	OS (months)
Van Den Bent et al. [15]	Phase II rand	108	BCNU or TMZ vs Erlotinib	2.4	24.1	7.3
Van Den Bent et al. [15]	Phase II rand	54	BCNU or TMZ vs Erlotinib	1.8	11.4	7.7
Brandes et al. [33]	Phase II	40	BCNU	NA	17.5	7.5
Addeo et al. [18]	Phase II	40	Fotemustine	6.7	61	11.1
Brada et al. [14]	Phase II	126	TMZ	2.1	18	5.4
Wich et al. [29]	Phase II	64	TMZ 1wk on/1 wk off	5.5	43.8	NA
Brada et al. [21]	Phase II rand	87	TMZ 5 days	5	NA	8.5
		81	TMZ 21 days	4.2		6.6
		162	PCV	3.6		6.7

TMZ temozolomide, NA not available, mos months, PFS6 progression free at 6 months

ISSN: 1471-2407