Table 2 Characteristics of patients in relation to different therapeutic approaches: combined treatment (chemotherapy CT, Surgery and Radiotherapy RT) versus chemotherapy only according to gender, age, KPS , MGMT promoter status, IDH mutation, time between initial diagnosis and recurrence and recurrent tumor volume
Factors | CT + surgery and/or RT n. pts 21 (49 %) | CT only n. pts 22 (51 %) | p value |
|---|---|---|---|
Gender | |||
Female | 10 (49) | 11 (50) | 0.9 |
Male | 11 (51) | 11 (50) | |
Median age | 50 years (range 27–75 years) | 53 years (range 38–80 year) | 0.4 |
MGMT promoter status | |||
Methylated | 9 | 9 | 0.9 |
Unmethylated | 4 | 4 | |
Unknown | 8 | 9 | |
IDH mutation | |||
Present | 5 | 1 | 0.17 |
Absent | 8 | 12 | |
Unknown | 8 | 9 | |
KPS | |||
100 | 11 | 0 | <0.01 |
90 | 5 | 14 | |
80 | 2 | 0 | |
70 | 3 | 8 | |
Time to Relapse from initial diagnosis | |||
≤ 12 months | 6 | 15 | <0.01 |
> 12–24 months | 7 | 6 | |
> 24 months | 8 | 1 | |
Median volume of recurrent disease (cm3) | |||
< 35 cm3 | 10 | 10 | 0.7 |
≥ 35 cm3 | 11 | 12 | |