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Table 2 Characteristics of patients in relation to different therapeutic approaches: combined treatment (chemotherapy CT, Surgery and Radiotherapy RT) versus chemotherapy only according to gender, age, KPS , MGMT promoter status, IDH mutation, time between initial diagnosis and recurrence and recurrent tumor volume

From: Multimodality therapy approaches, local and systemic treatment, compared with chemotherapy alone in recurrent glioblastoma

Factors CT + surgery and/or RT n. pts 21 (49 %) CT only n. pts 22 (51 %) p value
Gender
 Female 10 (49) 11 (50) 0.9
 Male 11 (51) 11 (50)
Median age 50 years (range 27–75 years) 53 years (range 38–80 year) 0.4
MGMT promoter status
 Methylated 9 9 0.9
 Unmethylated 4 4
 Unknown 8 9
IDH mutation
 Present 5 1 0.17
 Absent 8 12
 Unknown 8 9
KPS
 100 11 0 <0.01
 90 5 14
 80 2 0
 70 3 8
Time to Relapse from initial diagnosis
  ≤ 12 months 6 15 <0.01
  > 12–24 months 7 6
  > 24 months 8 1
Median volume of recurrent disease (cm3)
  < 35 cm3 10 10 0.7
  ≥ 35 cm3 11 12
  1. MGMT methylguanine-DNA methyltransferase, IDH Isocitrate dehydrogenase