Skip to main content

Table 1 Immunohistochemical analysis

From: PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study, pre-operative recognition of high risk endometrial carcinoma: a multicentre prospective cohort study

Immunohistochemical marker Results Ref.
IMP3 Insulin-like growth factor II mRNA-binding protein 3 IMP3 is more frequently expressed in UPSC and CCC than in EEC (resp. 78 %, 57 % and 15 % of the tumours were positive). [21]
P53   P53 is more expressed in non-endometrioid endometrial carcinomas than in EEC. Expression is also related to higher tumour grade. [19]
ER and PR Oestrogen and progesterone receptor Negative receptors were associated with lymph node metastasis and decreased survival. ER and PR expression is lower in non-endometrioid endometrial carcinomas than in EEC. [20, 34]
MLH1 MutL homolog 1 Loss of expression of mismatch repair proteins is seen in high grade EEC and not in UPSC and CCC. Loss of MLH1 expression is associated with longer survival. [35, 36]
PTEN Phosphatase and tensin homologue PTEN positivity is more frequently found in UPSC than EEC. [19]
Beta-catenin   Positive beta-catenin expression is associated with decreased stage, decreased grade and negative lymph node status [37]
P16   Loss of p16 expression is significantly correlated with high FIGO stage and serous and clear cell histological subtype. [38]
Ki-67   Higher Ki-67 expression is associated with higher tumour grade. UPSC and CCC show higher Ki-67 proliferation index than EEC. [34]
Stathmin   Stathmin overexpression was associated with non-endometrioid histology, high grade and poor disease-specific survival. [39]
ARID1A AT-rich interactive domain 1A gene Loss of ARID1A expression is significantly more frequent in high grade EEC compared to UPSC. [40]
L1CAM L1 cell adhesion molecule L1CAM is associated with higher grade and non-endometrioid histology. Moreover, L1CAM positive EC have statistical significant poorer disease-free survival and overall survival. [22]
  1. UPSC = Uterine papillary serous carcinoma; CCC = Clear Cell Carcinoma; EEC = Endometrioid endometrial carcinoma; EC = endometrial carcinoma; FIGO = Fédération Internationale de Gynécologie et d’Obstétrique