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Table 1 Immunohistochemical analysis

From: PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study, pre-operative recognition of high risk endometrial carcinoma: a multicentre prospective cohort study

Immunohistochemical marker

Results

Ref.

IMP3

Insulin-like growth factor II mRNA-binding protein 3

IMP3 is more frequently expressed in UPSC and CCC than in EEC (resp. 78 %, 57 % and 15 % of the tumours were positive).

[21]

P53

 

P53 is more expressed in non-endometrioid endometrial carcinomas than in EEC. Expression is also related to higher tumour grade.

[19]

ER and PR

Oestrogen and progesterone receptor

Negative receptors were associated with lymph node metastasis and decreased survival. ER and PR expression is lower in non-endometrioid endometrial carcinomas than in EEC.

[20, 34]

MLH1

MutL homolog 1

Loss of expression of mismatch repair proteins is seen in high grade EEC and not in UPSC and CCC. Loss of MLH1 expression is associated with longer survival.

[35, 36]

PTEN

Phosphatase and tensin homologue

PTEN positivity is more frequently found in UPSC than EEC.

[19]

Beta-catenin

 

Positive beta-catenin expression is associated with decreased stage, decreased grade and negative lymph node status

[37]

P16

 

Loss of p16 expression is significantly correlated with high FIGO stage and serous and clear cell histological subtype.

[38]

Ki-67

 

Higher Ki-67 expression is associated with higher tumour grade. UPSC and CCC show higher Ki-67 proliferation index than EEC.

[34]

Stathmin

 

Stathmin overexpression was associated with non-endometrioid histology, high grade and poor disease-specific survival.

[39]

ARID1A

AT-rich interactive domain 1A gene

Loss of ARID1A expression is significantly more frequent in high grade EEC compared to UPSC.

[40]

L1CAM

L1 cell adhesion molecule

L1CAM is associated with higher grade and non-endometrioid histology. Moreover, L1CAM positive EC have statistical significant poorer disease-free survival and overall survival.

[22]

  1. UPSC = Uterine papillary serous carcinoma; CCC = Clear Cell Carcinoma; EEC = Endometrioid endometrial carcinoma; EC = endometrial carcinoma; FIGO = Fédération Internationale de Gynécologie et d’Obstétrique