|
IMP3
|
Insulin-like growth factor II mRNA-binding protein 3
|
IMP3 is more frequently expressed in UPSC and CCC than in EEC (resp. 78 %, 57 % and 15 % of the tumours were positive).
|
[21]
|
|
P53
| |
P53 is more expressed in non-endometrioid endometrial carcinomas than in EEC. Expression is also related to higher tumour grade.
|
[19]
|
|
ER and PR
|
Oestrogen and progesterone receptor
|
Negative receptors were associated with lymph node metastasis and decreased survival. ER and PR expression is lower in non-endometrioid endometrial carcinomas than in EEC.
|
[20, 34]
|
|
MLH1
|
MutL homolog 1
|
Loss of expression of mismatch repair proteins is seen in high grade EEC and not in UPSC and CCC. Loss of MLH1 expression is associated with longer survival.
|
[35, 36]
|
|
PTEN
|
Phosphatase and tensin homologue
|
PTEN positivity is more frequently found in UPSC than EEC.
|
[19]
|
|
Beta-catenin
| |
Positive beta-catenin expression is associated with decreased stage, decreased grade and negative lymph node status
|
[37]
|
|
P16
| |
Loss of p16 expression is significantly correlated with high FIGO stage and serous and clear cell histological subtype.
|
[38]
|
|
Ki-67
| |
Higher Ki-67 expression is associated with higher tumour grade. UPSC and CCC show higher Ki-67 proliferation index than EEC.
|
[34]
|
|
Stathmin
| |
Stathmin overexpression was associated with non-endometrioid histology, high grade and poor disease-specific survival.
|
[39]
|
|
ARID1A
|
AT-rich interactive domain 1A gene
|
Loss of ARID1A expression is significantly more frequent in high grade EEC compared to UPSC.
|
[40]
|
|
L1CAM
|
L1 cell adhesion molecule
|
L1CAM is associated with higher grade and non-endometrioid histology. Moreover, L1CAM positive EC have statistical significant poorer disease-free survival and overall survival.
|
[22]
|
