Immunohistochemical marker | Results | Ref. | |
---|---|---|---|
IMP3 | Insulin-like growth factor II mRNA-binding protein 3 | IMP3 is more frequently expressed in UPSC and CCC than in EEC (resp. 78Â %, 57Â % and 15Â % of the tumours were positive). | [21] |
P53 | Â | P53 is more expressed in non-endometrioid endometrial carcinomas than in EEC. Expression is also related to higher tumour grade. | [19] |
ER and PR | Oestrogen and progesterone receptor | Negative receptors were associated with lymph node metastasis and decreased survival. ER and PR expression is lower in non-endometrioid endometrial carcinomas than in EEC. | |
MLH1 | MutL homolog 1 | Loss of expression of mismatch repair proteins is seen in high grade EEC and not in UPSC and CCC. Loss of MLH1 expression is associated with longer survival. | |
PTEN | Phosphatase and tensin homologue | PTEN positivity is more frequently found in UPSC than EEC. | [19] |
Beta-catenin | Â | Positive beta-catenin expression is associated with decreased stage, decreased grade and negative lymph node status | [37] |
P16 | Â | Loss of p16 expression is significantly correlated with high FIGO stage and serous and clear cell histological subtype. | [38] |
Ki-67 | Â | Higher Ki-67 expression is associated with higher tumour grade. UPSC and CCC show higher Ki-67 proliferation index than EEC. | [34] |
Stathmin | Â | Stathmin overexpression was associated with non-endometrioid histology, high grade and poor disease-specific survival. | [39] |
ARID1A | AT-rich interactive domain 1A gene | Loss of ARID1A expression is significantly more frequent in high grade EEC compared to UPSC. | [40] |
L1CAM | L1 cell adhesion molecule | L1CAM is associated with higher grade and non-endometrioid histology. Moreover, L1CAM positive EC have statistical significant poorer disease-free survival and overall survival. | [22] |