Fig. 4
Combinatory cytotoxicity of replication-competent Ad and Ad5/p53. a Cells were infected with AdF35/MK, Ad5/p53, or AdF35/MK (at indicated doses) plus Ad5/p53 (1.25x104 vp/cell). Relative viability of cells was examined with the WST assay and SE bars are shown (n = 3). CI values in the combination of AdF35/MK and Ad5/p53 in respective Fa points were shown. b Cells were infected with AdF35/Sur, Ad5/p53, or AdF35/Sur plus Ad5/p53 (1.25x104 vp/cell). Relative viability of cells was examined with the WST assay and SE bars are shown (n = 3). CI values in the combination of AdF35/Sur and Ad5/p53 in respective Fa points were shown. CI < 1, CI = 1 and CI > 1 indicate synergistic, additive and antagonistic actions, respectively. *P < 0.01; comparing between (A) AdF35/MK + Ad5/p53- or (B) AdF35/Sur + Ad5/p53-infected cells and (A) AdF35/MK-, Ad5/p53-, (B) AdF35/Sur- or Ad5/p53-infected cells