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Fig. 5 | BMC Cancer

Fig. 5

From: A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

Fig. 5

Heterotypic 3D-microtissue analysis after irradiation and concurrent Vinblastine treatment. a Merged and single GFP/RFP image examples of T47D-RFP/NHDF-GFP co-cultures with selected population for μm2 quantification after irradiation. b RFP and GFP plot (area in μm2) for T47D-RFP and NHDF-GFP heterotypic 3D-microtissues after treatment with 0 Gy and 2 Gy irradiation. c Co-cultures of T47D-RFP; MDA-MB-361-RFP and MDA-MB-231-RFP with NHDF-GFP growth quantification at day 11. RFP area (μm2) was analysed after 0 Gy and 2 Gy irradiation with concurrent 100 nM Vinblastine treatment. Data are averages ± SD, * indicate statistically (t-test) significant changes to corresponding control with Vinblastine treatment at 0 Gy, *p < 0.05; **p < 0.001

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