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Table 3 Cox regression analyses by HER2 status in 458 women with a primary DCIS

From: The prognostic role of HER2 expression in ductal breast carcinoma in situ (DCIS); a population-based cohort study

 

DCIS

 

HER2 positive

HER2 negative

 

HR (95 % CI)

HR (95 % CI)

Ipsilateral Breast Events (IBE)

  

BCS (n = 331) (events = 95)

  

 Univariate HR (95 % CI)

1.20 (0.78–1.85)

(Ref)

aAdjusted HR (95 % CI)

1.27 (0.83–1.96)

(Ref)

bAdjusted HR (95 % CI)

1.17 (0.75–1.83)

(Ref)

cAdjusted HR (95 % CI)

1.22 (0.76–1.95)

(Ref)

BCS, in situ IBEs (events = 49)

  

 Univariate HR (95 % CI)

1.63 (0.92–2.89)

(Ref)

aAdjusted HR (95 % CI)

1.76 (0.99–3.11)

(Ref)

bAdjusted HR (95 % CI)

1.40 (0.77–2.54)

(Ref)

cAdjusted HR (95 % CI)

1.65 (0.88–3.11)

(Ref)

BCS, invasive IBEs (events = 46)

  

 Univariate HR (95 % CI)

0.78 (0.40–1.55)

(Ref)

aAdjusted HR (95 % CI)

0.83 (0.42–1.64)

(Ref)

bAdjusted HR (95 % CI)

0.87 (0.43–1.75)

(Ref)

cAdjusted HR (95 % CI)

0.80 (0.38–1.66)

(Ref)

Invasive Breast Cancer Recurrence (IBCR)

  

All patients (n = 420) (Events = 102)

  

 Univariate HR (95 % CI)

0.60 (0.38–0.94)

(Ref)

aAdjusted HR (95 % CI)

0.58 (0.38–0.95)

(Ref)

bAdjusted HR (95 % CI)

0.59 (0.37–0.95)

(Ref)

cAdjusted HR (95 % CI)

0.59 (0.36–0.98)

(Ref)

  1. BCS breast conserving surgery
  2. aAdjusted for radiotherapy
  3. bAdjusted for radiotherapy, age at diagnosis (continuous) and size
  4. cAdjusted for radiotherapy, age at diagnosis and ER