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Table 1 Baseline characteristics by HER2 status in 458 women with a primary DCIS

From: The prognostic role of HER2 expression in ductal breast carcinoma in situ (DCIS); a population-based cohort study

Characteristics All HER2 positive HER2 negative   HER2 missing
(n = 458) (n = 132) (n = 288) (n = 38)
  n (%) n (%) n (%) P-valuea n (%)
 Age (years) mean (n = 458) 58.6 57.4 59.2 0.13 58.8
Detection mode (n = 457)      
 Screening 345 (75.5 %) 108 (81.8 %) 210 (73.2 %)   27 (71.1 %)
 Clinically 112 (24.5 %) 24 (18.2 %) 77 (26.8 %) 0.05 11 (28.9 %)
Type of Surgery (n = 457)      
 BCS 359 (78.6 %) 98 (74.2 %) 233 (81.2 %)   28 (73.7 %)
 Mastectomy 98 (21.4 %) 34 (25.8 %) 54 (18.8 %) 0.11 10 (26.3 %)
Radiotherapy (n = 359)      
 Yes 158 (44.0 %) 49 (50.0 %) 100 (42.9 %)   9 (32.1 %)
 No 201 (56.0 %) 49 (50.0 %) 133 (57.1 %) 0.32 19 (67.9 %)
Tumor size (mm) (n = 409)      
  ≤ 25 294 (71.9 %) 68 (61.3 %) 203 (77.2 %)   23 (65.7 %)
  > 25 or multifocal 115 (28.1 %) 43 (38.7 %) 60 (22.8 %) 0.002 12 (34.3 %)
Nuclear grade (n = 458)      
 Grade 1 42 (9.2 %) 1 (0.8 %) 34 (11.8 %)   7 (18.4 %)
 Grade 2 176 (38.4 %) 20 (15.1 %) 145 (50.3 %)   11 (28.9 %)
 Grade 3 240 (52.4 %) 111 (84.1 %) 109 (37.8 %) <0.001 20 (52.6 %)
ER status (n = 419)      
 Positive 307 (73.3 %) 59 (45.7 %) 243 (86.5 %)   5 (55.6 %)
 Negative 112 (26.7 %) 70 (54.3 %) 38 (13.5 %) <0.001 4 (44.4 %)
PR status (n = 409)      
 Positive 213 (52.1 %) 35 (28.2 %) 175 (62.9 %)   4 (57.1 %)
 Negative 196 (47.93 %) 89 (71.8 %) 103 (37.1 %) <0.001 3 (42.9 %)
  1. BCS breast conserving surgery, RT postoperative radiotherapy
  2. aComparisons between HER2-negative and HER2-positive DCIS were made by χ2-test, except for age and size that was compared by T-test