Fig. 3

Invasive recurrence-free-survival according to HER2 of the primary DCIS, stratified for ER status and age, respectively. Kaplan-Meier analyses stratified for ER status of the primary DCIS, demonstrating invasive recurrence-free survival (IBCR) with respect to HER2 status of the primary DCIS among ER negative (a) and ER positive DCIS patients (b). Additional Kaplan-Meier curves show analyses stratified for age at diagnosis (≤50 years/> 50 years) displaying invasive recurrence-free survival (IBCR) according to HER2 status of the primary DCIS among young patients (≤50 years at diagnosis), (c) and older patients with age 50 years or above at diagnosis (d)