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Table 1 Selected proteins from quantitative proteomic analysis of astrocytomas and oligodendriomas tumor samples (n = 4). Proteins are expressed as log2 fold change in relation to non-neoplastic brain tissue (NN)

From: Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma

Id Protein

Acc

NN

AST II

GBM SS

GBM LS

OLI II

OLI III

Spectra Count

% Seq Cov

blocked t-test (p-value ASTRO)a

blocked t-test (p-value OLI)b

blocked ANOVA test (p-value ASTRO/OLI)c

Epidermal growth factor receptor

EGFR

Ref

0.2

1.5

2.2

0.3

0.6

20

13.2

0.0023

0.93

<0.0001

Nucleophosmin

NPM1

Ref

0.2

1.1

1.1

0.8

1.3

14

32.3

0.0049

<0.0001

<0.0001

78 kDa glucose-regulated protein

GRP78 (HSPA5)

Ref

0.3

1.1

0.9

0.2

0.6

44

43.0

<0.0001

0.0008

0.037

Phosphatidylethanolamine-binding protein 1

PEBP1 (RKIP)

Ref

-0.4

-1.0

-1.1

-0.6

-1.4

36

79.1

<0.0001

<0.0001

<0.0001

Heat shock protein beta-1

HSPB1

Ref

0.1

1.6

0.8

0.3

0.5

9

49.8

0.00045

0.89

0.28

RNA-binding protein Nova-1

NOVA1

Ref

0.1

0.9

2.2

0.8

1.3

3

7.8

0.120

0.011

0.0082

Endoplasmin

(ENPL) HSP90B1

Ref

0.2

1.0

0.9

0.6

1.0

44

25.8

<0.0001

<0.0001

<0.0001

Nucleolin

NCL

Ref

0.2

1.3

1.1

1.0

1.9

27

25.1

<0.0001

<0.0001

<0.0001

  1. Statistical test for ratio-based normalization of isobaric tags (Scaffold v.4.3.0) - The samples were grouped as follows:
  2. aastrocytomas = NN, AST II, GBM-SS and GBM-LS
  3. boligodendroglioma = NN, OLI II and OLI III
  4. cstrocytoma and oligodendroglioma = NN, AST II and OLI II