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Table 4 Results of Overall Survival Analysis by Cox Proportional Hazards Model for the untreated subgroup

From: Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer

Prognostic Factor Univariate (n = 142) Multivariate (n = 129c)
  HR (95 % CI) P-value HR (95 % CI) P-value
Menacalc
  High vs. Low 2.14 (1.05, 4.58) 0.0445 3.80 (1.58, 9.97) 0.0052
Her2a
  Positive vs. Negative 1.59 (0.43, 4.31) 0.4234 1.35 (0.34, 4.02) 0.6376
Tumor Size
  ≥2 cm vs. <2 cm 2.05 (1.01, 4.22) 0.0508 1.41 (0.62, 3.23) 0.4178
ERa
  Negative vs. Positive 1.62 (0.68, 3.51) 0.2504 0.99 (0.36, 2.51) 0.9863
PR*
  Positive vs. Negative 2.84 (1.27, 7.05) 0.0173 NAb NAb
Histological grade
  Grade 2-3 vs. Grade 1 2.61 (1.09, 7.43) 0.0505 1.85 (0.67, 5.84) 0.2719
  ND vs. Grade 1 1.46 (0.39, 5.23) 0.5667 1.34 (0.33, 5.03) 0.6763
Lymphatic invasion
  Present vs. Absent 2.11 (0.81, 4.75) 0.0993 1.63 (0.54, 4.16) 0.3537
Age, years
  ≥50 vs. <50 2.41 (1.03, 6.77) 0.0666 3.03 (1.17, 9.11) 0.0348
  1. aIHC marker
  2. bPR was not included as ER and PR are correlated
  3. cTumors excluded if missing data for either Her2 or ER