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Table 3 Results of Overall Survival Analysis by Cox Proportional Hazards Model for the full dataset

From: Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer

Prognostic Factor Univariate (n = 403) Multivariate (n = 360c)
  HR (95 % CI) P-value HR (95 % CI) P-value
Menacalc
  High vs. Low 1.84 (1.08, 3.14) 0.0248 2.18 (1.19, 4.00) 0.0199
Her2a
  Positive vs. Negative 1.71 (0.77, 3.79) 0.1855 1.43 (0.58, 3.53) 0.4341
Tumor Size
  ≥2 cm vs. <2 cm 1.40 (0.83, 2.35) 0.2024 1.45 (0.80, 2.66) 0.2234
ERa
  Negative vs. Positive 1.18 (0.65, 2.13) 0.5858 1.09 (0.57, 2.08) 0.7952
PRa
  Positive vs. Negative 2.36 (1.32, 4.25) 0.0040 NAb NAb
Histological grade
  Grade 2-3 vs. Grade 1 1.62 (0.82, 3.22) 0.1682 1.27 (0.59, 2.72) 0.5450
  ND vs. Grade 1 1.06 (0.33, 3.42) 0.9264 0.75 (0.22, 2.49) 0.6354
Lymphatic invasion
  Present vs. Absent 1.78 (0.97, 3.26) 0.0614 1.67 (0.85, 3.30) 0.1359
Treatment
  Yes vs. No 0.60 (0.35, 1.00) 0.0514 0.54 (0.29, 0.99) 0.0454
Age, years
  ≥50 vs. <50 1.90 (1.06, 3.43) 0.0319 1.93 (1.02, 3.65) 0.0425
  1. aIHC marker
  2. bPR was not included as ER and PR are correlated
  3. cTumors excluded if missing data for either Her2 or ER
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