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Fig. 5 | BMC Cancer

Fig. 5

From: Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes

Fig. 5

Transcriptional and translational validation array CGH outcomes. a Histograms of QPCR analysis showing transcriptional amplification of CD1C, FOXP2, RALYL, NBPF20, and MAL2, and suppression of APOBEC3B, SLC25A17, EP300, L3MBTL2, SERHL, A4GALT, POLDIP3, and ADAM5 in clones of MSDACs compared with SH-SY5Y cells. b Representative immunoblots showing the expression level of RALYL and FOXP2 (both showed gain in Array CGH analysis) in two different clones of metastatic site derived aggressive cells (MSDAC) in comparison with the parental SH-SY5Y cells and in the metastatic tumors derived from three different animals bearing high-risk aggressive neuroblastoma (NB-MT-AD) in comparison with the non-metastatic primary xenograft (NB-NM-PX). Side Panel: Histograms of Quantity one densitometry analysis showing robust increase in RALYL and FOXP2 expression in MSDACs as well as in metastatic tumors in vivo

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BMC Cancer

ISSN: 1471-2407

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