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Table 1 Average global DNA methylation and ancestral contributions in melanoma and breast cancer cases and controls

From: Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients

  N Cases N Controls P value
Global DNA methylation (±SD)      
 Melanomaa 42 2.54 ± 0.37 % 46 2.79 ± 0.27 % 9.96e−4
 Breast cancera 86 2.33 ± 0.48 % 92 2.77 ± 0.77 % 5.96e−5
Global DNA methylation-Gender      
 Melanoma      
  Female 22 2.48 ± 0.42 % 29 2.79 ± 0.24 % 0.269b
  Male 20 2.63 ± 0.30 % 17 2.80 ± 0.32 % 0.198c
Ancestry (±SD)      
 Melanoma 49   73   
  European   95.04 ± 6.48 %   93.32 ± 11.39 % 0.184
  Native American   3.33 ± 5.81 %   4.94 ± 7.71 % 0.211
  African   1.16 ± 3.37 %   1.74 ± 4.84 % 0.120
 Breast cancer 179   209   
  European   76.89 ± 12.95 %   76.49 ± 14.26 % 0.927
  Native American   12.86 ± 10.46 %   13.85 ± 11.37 % 0.229
  African   10.25 ± 8.30 %   9.66 ± 7.55 % 0.420
  1. aLogistic regression for Melanoma P = 7.10e−4 and Breast cancer P = 5.47e−4, adjusted by ancestry and age
  2. bComparison between females and males in cases.
  3. cComparison between females and males in controls