Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients

BMC Cancer

Table 1 Average global DNA methylation and ancestral contributions in melanoma and breast cancer cases and controls

	N	Cases	N	Controls	P value
Global DNA methylation (±SD)
Melanoma^a	42	2.54 ± 0.37 %	46	2.79 ± 0.27 %	9.96e⁻⁴
Breast cancer^a	86	2.33 ± 0.48 %	92	2.77 ± 0.77 %	5.96e⁻⁵
Global DNA methylation-Gender
Melanoma
Female	22	2.48 ± 0.42 %	29	2.79 ± 0.24 %	0.269^b
Male	20	2.63 ± 0.30 %	17	2.80 ± 0.32 %	0.198^c
Ancestry (±SD)
Melanoma	49		73
European		95.04 ± 6.48 %		93.32 ± 11.39 %	0.184
Native American		3.33 ± 5.81 %		4.94 ± 7.71 %	0.211
African		1.16 ± 3.37 %		1.74 ± 4.84 %	0.120
Breast cancer	179		209
European		76.89 ± 12.95 %		76.49 ± 14.26 %	0.927
Native American		12.86 ± 10.46 %		13.85 ± 11.37 %	0.229
African		10.25 ± 8.30 %		9.66 ± 7.55 %	0.420

^aLogistic regression for Melanoma P = 7.10e⁻⁴ and Breast cancer P = 5.47e⁻⁴, adjusted by ancestry and age
^bComparison between females and males in cases.
^cComparison between females and males in controls

ISSN: 1471-2407