Table 7 Subgroup analysis for disease-specific survival
From: Lymph node density as a prognostic variable in node-positive bladder cancer: a meta-analysis
| Â | No. of included articles | No. of cases | Pooled HR (95Â % CI) | Chi2 (p value) | I2 | Ph* |
|---|---|---|---|---|---|---|
Publication year | Â | Â | Â | Â | Â | 0.0517 |
2003–2010 | 4 | 375 | 1.61 (1.09–2.38) | 7.42 (0.06) | 60 % |  |
2011–2014 | 6 | 2591 | 1.51 (1.16–1.97) | 12.22 (0.03) | 59 % |  |
Region | Â | Â | Â | Â | Â | 0.3206 |
USA | 3 | 1979 | 1.57 (1.10–2.22) | 11.45 (0.003) | 83 % |  |
Europe | 5 | 1679 | 1.54 (1.02–2.31) | 14.19 (0.007) | 72 % |  |
Asia | 2 | 261 | 1.61 (1.08–2.39) | 0.46 (0.5) | 0 % |  |
No. of patients | Â | Â | Â | Â | Â | 0.0015 |
<100 | 5 | 331 | 1.40 (0.82–2.40) | 12.35 (0.01) | 68 % |  |
≥100 | 5 | 2635 | 1.55 (1.23–1.95) | 14.06 (0.007) | 72 % |  |
Median follow-up* | Â | Â | Â | Â | Â | 0.0017 |
<36 months | 4 | 1643 | 1.85 (1.53–2.24) | 2.58 (0.46) | 0 % |  |
≥36 months | 5 | 544 | 1.20 (0.91–1.59) | 7.43 (0.11) | 46 % |  |
Analysis results | Â | Â | Â | Â | Â | 0.1626 |
Not significant | 4 | 382 | 1.14 (0.69–1.87) | 7.37 (0.06) | 59 % |  |
Significant | 6 | 2584 | 1.69 (1.31–2.17) | 18.98 (0.002) | 74 % |  |
Quality scale | Â | Â | Â | Â | Â | 0.0233 |
≤4 | 7 | 2361 | 1.60 (1.26–2.03) | 16.99 (0.009) | 65 % |  |
>4 | 3 | 605 | 1.08 (0.51–2.30) | 8.91 (0.01) | 78 % |  |