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Table 2 Amino acid residues at the binding sites of SPR-SSZ, SPR-NADP+, and SPR-SPR complexes

From: Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target

SSZ NADP+ SPR Dimer
Pocket Pocket Interface
Gly11 Gly11 -
Ser13 Ser13 -
Arg14 Arg14 -
  Gly15 -
Phe16 Phe16 -
Ala38 - -
Arg39 Arg39 -
- Asn40 -
- Ala65 -
- Asp66 -
- Leu67 -
- - Glu70
Asn97 Asn97 -
Ala98 - -
Gly99 - -
Ser100 - -
- - Gly107
- - Phe108
- - Val109
- - Asp110
- - Leu111
- - Ser114
- - Val117
- - Asn118
- - Trp121
- - Ala122
- Leu123 -
- - Thr126
- - Leu129
- - Ser133
- - Lys137
- Ile152 -
- Ser153 -
- - Pro160
- - Phe161
- - Lys162
- - Gly163
- - Ala165
Tyr167 Tyr167 -
- - Cys168
- - Ala169
- Lys171 -
- - Ala173
- - Met176
- - Leu177
- - Val180
- - Leu181
- - Leu183
- - Glu184
- Pro195 -
- Gly196 -
- Pro197 -
Leu198 Leu198 -
Thr200 Thr200 -
Met202 Met202 -
- Gln203 -
  1. Cutoff distance: 3.6 Angstrom