Table 2 Amino acid residues at the binding sites of SPR-SSZ, SPR-NADP+, and SPR-SPR complexes

SSZ

NADP+

SPR Dimer

Pocket

Pocket

Interface

Gly11

Gly11

-

Ser13

Ser13

-

Arg14

Arg14

-

Gly15

-

Phe16

Phe16

-

Ala38

-

-

Arg39

Arg39

-

-

Asn40

-

-

Ala65

-

-

Asp66

-

-

Leu67

-

-

-

Glu70

Asn97

Asn97

-

Ala98

-

-

Gly99

-

-

Ser100

-

-

-

-

Gly107

-

-

Phe108

-

-

Val109

-

-

Asp110

-

-

Leu111

-

-

Ser114

-

-

Val117

-

-

Asn118

-

-

Trp121

-

-

Ala122

-

Leu123

-

-

-

Thr126

-

-

Leu129

-

-

Ser133

-

-

Lys137

-

Ile152

-

-

Ser153

-

-

-

Pro160

-

-

Phe161

-

-

Lys162

-

-

Gly163

-

-

Ala165

Tyr167

Tyr167

-

-

-

Cys168

-

-

Ala169

-

Lys171

-

-

-

Ala173

-

-

Met176

-

-

Leu177

-

-

Val180

-

-

Leu181

-

-

Leu183

-

-

Glu184

-

Pro195

-

-

Gly196

-

-

Pro197

-

Leu198

Leu198

-

Thr200

Thr200

-

Met202

Met202

-

-

Gln203

-