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Table 1 SPR mRNA correlations in public NB mRNA expression datasets

From: Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target

Dataset

SPR mRNA expression correlations

Micro-array data

Name

Samples

Survival/prognosis

MYCN amplification

Array Type

GSE

Delattre

64

n.d.

positive (6.8 • 10-6)

Affymetrix HG-U133 Plus 2.0

12460

Hiyama

51

negative (0.02)

positive (2.8 • 10-3)

Affymetrix HG-U133 Plus 2.0

16237

Jagannathan

100

negative (0.02)

positive (1.7 • 10-3)

Illumina Human WG 6V2

19274

Kocak

649

n.d.

positive (7.9 • 10-15)

Agilent Human 44K Oligo

45547

Łastowska

30

n.d.

positive (2.6 • 10-4)

Affymetrix HG-U133 Plus 2.0

13136

Maris

101

n.d.

n.s.

Affymetrix HG-U95A

3960

Seeger

117

negative (1.4 • 10-4)

n.d.

Affymetrix HG-U133A

3446

Versteeg

88

negative (0.02)

n.s.

Affymetrix HG-U133 Plus 2.0

16476

Zhang

498

negative (2.1 • 10-6)

positive (4.6 • 10-4)

Agilent Human 44K Oligo

49710

  1. Legend: The Albino-28 (GSE7529), Khan-47 (GSE27608), and Seeger-102 (GSE3446) do not contain sufficient clinical data and were not analyzed. Data were analyzed as described in the Materials and Methods. The first two columns represent name and sample size of the dataset. The two central columns show the results of SPR mRNA expression correlation analyses: with survival and/or prognosis, and with MYCN amplification. Negative or positive in the two central columns means that SPR mRNA expression correlates negative or positive with survival/good prognosis and MYCN amplification, respectively (outcomes of Kruskal-Wallis correlation tests, the number in parentheses is the P value, n.s. means not significant, n.d. means not determined (data not present in the dataset)). Kocak-649 and Zhang-498 contain some common samples. The last two columns list Array type and GEO GSE number on the NCBI GEO website where full data are available