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Table 1 SPR mRNA correlations in public NB mRNA expression datasets

From: Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target

Dataset SPR mRNA expression correlations Micro-array data
Name Samples Survival/prognosis MYCN amplification Array Type GSE
Delattre 64 n.d. positive (6.8 • 10-6) Affymetrix HG-U133 Plus 2.0 12460
Hiyama 51 negative (0.02) positive (2.8 • 10-3) Affymetrix HG-U133 Plus 2.0 16237
Jagannathan 100 negative (0.02) positive (1.7 • 10-3) Illumina Human WG 6V2 19274
Kocak 649 n.d. positive (7.9 • 10-15) Agilent Human 44K Oligo 45547
Łastowska 30 n.d. positive (2.6 • 10-4) Affymetrix HG-U133 Plus 2.0 13136
Maris 101 n.d. n.s. Affymetrix HG-U95A 3960
Seeger 117 negative (1.4 • 10-4) n.d. Affymetrix HG-U133A 3446
Versteeg 88 negative (0.02) n.s. Affymetrix HG-U133 Plus 2.0 16476
Zhang 498 negative (2.1 • 10-6) positive (4.6 • 10-4) Agilent Human 44K Oligo 49710
  1. Legend: The Albino-28 (GSE7529), Khan-47 (GSE27608), and Seeger-102 (GSE3446) do not contain sufficient clinical data and were not analyzed. Data were analyzed as described in the Materials and Methods. The first two columns represent name and sample size of the dataset. The two central columns show the results of SPR mRNA expression correlation analyses: with survival and/or prognosis, and with MYCN amplification. Negative or positive in the two central columns means that SPR mRNA expression correlates negative or positive with survival/good prognosis and MYCN amplification, respectively (outcomes of Kruskal-Wallis correlation tests, the number in parentheses is the P value, n.s. means not significant, n.d. means not determined (data not present in the dataset)). Kocak-649 and Zhang-498 contain some common samples. The last two columns list Array type and GEO GSE number on the NCBI GEO website where full data are available