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Fig. 7 | BMC Cancer

Fig. 7

From: The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts

Fig. 7

Inhibition of pulmonary metastasis by the combination of Tam and MSM in vivo. (a) A metastatic animal model showing the pulmonary metastasis analysis for the Tam, MSM, drug combination-treated, or vehicle-treated controls. (b) Graphical representation of pulmonary metastasis following treatment with Tam, MSM, or the drug combination with respect to percentage of the control. Statistical analyses were conducted using the ANOVA test (**P < 0.01 and ***P < 0.001). (c) Tissue protein analysis of various matrix metaloproteins and angiogenic factors after the treatment with Tam, MSM, or the drug combination for 24 h using western blotting. (d) Graphical analysis of different tissue proteins following exposure to Tam, MSM, or the drug combination

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BMC Cancer

ISSN: 1471-2407

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