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Fig. 5 | BMC Cancer

Fig. 5

From: The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts

Fig. 5

The combination of MSM and Tam synergistically inhibited migration and matrix metalloproteinases. (a) A wound healing assay showing the migration inhibition of MCF-7 cells treated with the drug combination and the individual agents for 24 h. (b) Relative inhibition of migration in MCF-7 cells as per the wound healing assay. Statistical analyses were conducted using t-tests (*P < 0.05 and **P < 0.01). (c) RT-PCR analysis of RNA levels of matrix metaloproteins after treatment with Tam, MSM, or the drug combination for 24 h in MCF-7 cells. (d) Graphical representation of RNA levels of matrix metaloproteins after treatment with Tam, MSM, or the drug combination for 24 h in MCF-7 cells. (e) Western blot analysis showing the levels of matrix metaloproteins in whole cell lysates following treatment with Tam, MSM, or their combination in MCF-7 cells. (f) Graphical representation of matrix metaloproteins in whole cell lysates following treatment with Tam, MSM, or their combination in MCF-7 cells

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BMC Cancer

ISSN: 1471-2407

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