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Fig. 4 | BMC Cancer

Fig. 4

From: The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts

Fig. 4

The combination of MSM and Tam synergistically inhibited invasion through STAT5b. (a) A Matrigel invasion assay showing the invasion inhibition of Tam, MSM, and the drug combination for 24 h in MCF-7 cells. (b) Graphical representation of the invasion assay results. (c) On-target inhibition of STAT5b inhibited the invasion in T47D cells. (d) Graphical representation of the relative inhibition of invasion after silencing of STAT5b. Statistical analyses were conducted using the ANOVA test (**P < 0.01 and ***P < 0.001)

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BMC Cancer

ISSN: 1471-2407

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