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Fig. 3 | BMC Cancer

Fig. 3

From: The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts

Fig. 3

The MSM-Tam combination synergistically inhibited the downstream targets of the STAT5b pathway. (a) Western blotting analysis showing total protein levels of the downstream targets of STAT5b following treatment with the drug combination in MCF-7 and T47D cells. (b) Graphical analysis of the action of the drug combination and the individual agents on the downstream targets of STAT5b in cytoplasmic proteins. (c) RT-PCR analysis of RNA levels of downstream targets of STAT5b after the treatment with Tam, MSM, and the drug combination for 24 h in MCF-7 and T47D cells. (d) Inhibition of RNA levels by the drug combination, Tam, and MSM relative to the percentage of 18 s RNA

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BMC Cancer

ISSN: 1471-2407

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