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Fig. 1 | BMC Cancer

Fig. 1

From: The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts

Fig. 1

Synergistic inhibition of cell proliferation by the combination of Tam and MSM and induction of apoptosis. (a) 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetra-zolium bromide assay for cell proliferation arrest by Tam, MSM, and their combinations in MCF-7 breast cancer cells. (b) Combination index plot for drug combination and table for various concentrations of Tam and MSM by Compusyn. (c) Apoptosis induced using MSM, Tam, or the combination in MCF-7 cells quantified using flow cytometry. Camptothecin was used as positive control. (d) Western blotting analysis of Bax protein levels in MCF-7 and T47D cells, and after treatment with Tam, MSM, or their combination for 24 h. (e) Graphical representation of Bax protein levels in MCF-7 and T47D cells, and after treatment with Tam, MSM, or their combination for 24 h

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BMC Cancer

ISSN: 1471-2407

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