Fig. 3

Cox regression multivariate analysis of breast cancer survival. Patients were divided into high and low expression groups relative to the median expression values (a, b). Cox regression analysis of survival according to the expression of (a), TMPRSS1 mRNA (median follow-up time 9.79 years); b, TMPRSS3 mRNA (median follow-up time 9.51 years); c, TMPRSS1 and TMPRSS3 mRNA (median follow-up time 9.79 years); and d, hepsin and TMPRSS3 protein expression (median follow-up time 11.05 years). In addition to expression levels, tumor grade, nodal status, tumor size, hormone receptor status, and histologic type were included in the multivariate analyses. Positive nodal status and large tumor size (T3, T4) were other parameters that were significantly associated with poorer breast cancer survival in the multivariate analyses