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Table 3 Ten signaling agents and their targets with dissociation constant

From: A microRNA molecular modeling extension for prediction of colorectal cancer treatment

Drug Target Dissociation constant (nM)
Dasatinib ABL1 0.53
  EPHA3 0.09
  EPHA5/8 0.24
  PDGFRA 0.47
  LYN 0.57
  KIT 0.62
  SRC 0.21
Erlotinib EGFR 0.67
  ERBB4 230
  LYN 530
  SRC 700
Everolimus MTOR 2.2
Gefitinib EGFR 1.0
  ERBB2 3500
  ERBB4 410
  LYN 990
Imatinib ABL1 12.0
  ABL2 10.0
  KIT 14.0
  PDGFRA 31.0
  PDGFRB 14.0
Lapatinib EGFR 2.4
  ERBB2 7.0
  ERBB4 54.0
Nilotinib KIT 22
  PDGFRB 22
Sorafenib DDR1 1.5
  DDR2 6.6
Sunitinib FLT3 0.47
  KIT 0.37
  PDGFRA 0.79
  PDGFRB 0.08
Temsirolimus MTOR 2.2
  VEGFR 0.75
  1. The experimentally measured dissociation constants of these signaling agents were mainly taken from Karaman et al. [35]