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Table 6 Specific toxicities, evaluated by cycles (total 284 cycles)

From: Pegylated liposomal doxorubicin (Lipo-Dox®) combined with cyclophosphamide and 5-fluorouracil is effective and safe as salvage chemotherapy in taxane-treated metastatic breast cancer: an open-label, multi-center, non-comparative phase II study

Toxicity Grade 1 Grade 2 Grade 3 Grade 4 Total
  n % n % n % n % n %
Leukopenia 7 (2 %) 18 (6 %) 19 (7 %) 5 (2 %) 49 (17 %)
Neutropenia 4 (1 %) 10 (4 %) 27 (10 %) 12 (4 %) 53 (19 %)
Neutropenic fever 1 (0 %) 2 (1 %) 2 (1 %) 0 (0 %) 5 (2 %)
Anemia 26 (9 %) 25 (9 %) 6 (2 %) 3 (1 %) 60 (21 %)
Thrombocytopenia 16 (6 %) 4 (1 %) 3 (1 %) 0 (0 %) 23 (8 %)
Mucositis 11 (4 %) 27 (10 %) 5 (2 %) 0 (0 %) 43 (15 %)
Hand-foot syndrome 39 (14 %) 16 (6 %) 4 (1 %) 0 (0 %) 59 (21 %)
Nausea 22 (8 %) 5 (2 %) 2 (1 %) 0 (0 %) 29 (10 %)
Vomiting 12 (4 %) 9 (3 %) 6 (2 %) 0 (0 %) 27 (10 %)
Anorexia 38 (13 %) 6 (2 %) 4 (1 %) 0 (0 %) 48 (17 %)
Diarrhea 16 (6 %) 6 (2 %) 0 (0 %) 0 (0 %) 22 (8 %)
Alopecia 35 (12 %) 3 (1 %) 0 (0 %) 0 (0 %) 38 (13 %)