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Table 2 Observed (O) and expected (E) numbers of second primary cancers after diagnosis of an initial uterine cancer (ICD-9 179, 182) in Taiwan 1979-2008

From: Increased risk of second primary malignancies following uterine cancer: a population-based study in Taiwan over a 30-year period

SPM site (ICD-9 code) Age of uterine cancer (years) (mean ± SD) Age of SPM (years) (mean ± SD) O E SIR (O/E) (95 % CI)
Head and neck 57.89 ± 11.95 63.67 ± 12.94 9 10.51 0.86 (0.39, 1.63)
Oral & pharynx (141, 143-5, 146,148-9) 49.50 ± 5.92 54.25 ± 8.96 4 4.81 0.83 (0.22, 2,13)
 Nasopharynx (147) 71.67 ± 8.33 77.00 ± 6.93 3 4.48 0.67 (0.13, 1.96)
 Larynx (161) 57 70 1 0.41 2.45 (0.03, 13.64)
 Major salivary glands (142) 51 55 1 0.80 1.24 (0.02, 6.92)
Digestive system 56.21 ± 10.12 63.28 ± 10.41 212 124.06 1.71 (1.49, 1.96)
 Esophagus (150) 58.00 ± 1.41 65.50 ± 7.78 2 1.57 1.28 (0.14, 4.61)
 Stomach (151) 59.92 ± 9.06 66.88 ± 8.59 25 17.09 1.46 (0.95, 2.16)
 Small intestine (152) 50.33 ± 10.45 56.50 ± 11.34 12 1.42 8.45 (4.36, 14.77)
 Colorectum (153,154) 54.70 ± 10.43 61.22 ± 10.42 119 53.05 2.24 (1.86, 2.68)
 Liver (155) 60.16 ± 6.81 69.09 ± 6.72 45 39.42 1.14 (0.83, 1.53)
 Biliary system (156) 63.67 ± 15.95 71.67 ± 13.43 3 4.82 0.62 (0.13, 1.82)
 Pancreas (157) 48.50 ± 12.57 54.17 ± 12.98 6 6.69 0.90 (0.33, 1.95)
Genital system 49.48 ± 12.52 52.57 ± 13.82 56 11.42 4.91 (3.71,6.37)
 Ovary (183) 48.40 ± 11.54 49.75 ± 11.43 40 9.65 4.15 (2.95, 5.64)
 Vagina and vulva (184) 52.19 ± 14.75 59.63 ± 16.92 16 1.77 9.06 (5.17, 14.71)
Urinary system 55.95 ± 13.10 64.14 ± 12.18 43 18.94 2.27 (1.64, 3.06)
 Urinary bladder (188) 53.89 ± 15.02 62.28 ± 14.42 18 7.79 2.31 (1.37, 3.65)
 Kidney (189) 57.44 ± 11.62 65.48 ± 10.38 25 11.16 2.24 (1.45, 3.31)
 Lung and bronchus (162) 58.63 ± 10.19 64.97 ± 10.99 72 36.81 1.96 (1.53, 2.46)
 Sarcoma (171) 48.50 ± 16.81 52.50 ± 16.45 6 6.77 0.89 (0.32, 1.93)
 Skin (173) 52.50 ± 11.57 59.14 ± 12.38 14 11.85 1.18 (0.65, 1.98)
 Breast (174) 53.41 ± 10.20 59.23 ± 10.46 95 66.51 1.43 (1.16, 1.75)
 Brain (191) 52.00 ± 9.02 54.75 ± 9.25 4 2.25 1.78 (0.48, 4.55)
 Thyroid (193) 55.46 ± 10.61 59.77 ± 11.50 13 9.84 1.32 (0.70, 2.26)
 Leukemia (204-8) 51.33 ± 7.12 58.00 ± 9.80 9 5.07 1.77 (0.81, 3.37)
 Lymphoma (200-3) 61.00 ± 7.62 67.57 ± 6.58 7 8.39 0.83 (0.33, 1.72)
 Others 50.27 ± 13.00 56.93 ± 13.80 15 12.54 1.20 (0.67, 1.97)
Total 55.01 ± 11.45 60.54 ± 12.08 555 324.95 1.71 (1.57, 1.86)
  1. Bold denotes statistical significance
  2. SD standard deviation, SIR standardized incidence ratio, SPM second primary malignancy, O observed numbers of SPMs, E expected numbers of SPMs, CI confidence interval