Table 3 Relative risk (RR) of cancer in offspring according to maternal hyperemesis gravidarum (HG)- status for selected types of cancer combined and separately, with 95 % confidence intervals (95 % CI)
N | Cases | Controls | Crude RR (95 % CI) | Adjusted RR* (95 % CI) | |
|---|---|---|---|---|---|
Total | 14.805 | HG+ 97 | HG+ 818 | 1.18 (0.95-1.46) | 1.19 (0.97-1.48) |
HG- 14.708 | HG- 146.891 | ||||
Leukemia | 5.114 | HG+ 28 | HG+ 280 | 0.99 (0.67-1.47) | 1.00 (0.68-1.48) |
HG-5.086 | HG- 50.845 | ||||
Central nervous | 4.524 | HG+ 29 | HG+ 242 | 1.20 (0.81-1.78) | 1.24 (0.84-1.83) |
system | HG- 4.495 | HG- 45.026 | |||
Lymphoma | 1.853 | HG+ 15 | HG+ 102 | 1.70 (0.98-2.96) | 1.68 (0.97-2.92) |
HG- 1.838 | HG- 19.973 | ||||
Testis | 847 | HG+ 4 | HG+ 51 | 0.87 (0.31-2.43) | 0.87 (0.31-2.43) |
HG- 843 | HG- 9.190 | ||||
Nephroblastoma | 441 | HG+ 8 | HG+ 48 | 1.97 (0.91-4.23) | 2.01 (0.93-4.34) |
HG- 433 | HG- 4.850 | ||||
Adrenal gland | 417 | HG+ 3 | HG+ 28 | 1.12 (0.34-3.75) | 1.14 (0.34-3.80) |
HG- 414 | HG- 4.567 | ||||
Primary bone | 394 | HG+ 2 | HG+ 15 | 1.40 (0.31-6.20) | 1.38 (0.31-6.15) |
HG-392 | HG- 4.286 | ||||
Retinoblastoma | 345 | HG+ 3 | HG+ 36 | 0.97 (0.29-3.20) | 0.97 (0.29-3.20) |
HG- 342 | HG- 3.725 | ||||
Thyroid gland | 343 | HG+ 4 | HG+ 21 | 2.11 (0.71-6.29) | 2.21 (0.73-6.71) |
HG- 339 | HG- 3.836 | ||||
Ovary | 296 | HG+ 1 | HG+ 20 | 0.50 (0.07-3.72) | 0.48 (0.06-3.62) |
HG- 295 | HG- 3.193 | ||||
Hepatoblastoma | 213 | HG+ 0 | HG+ 13 | - | - |
HG- 213 | HG- 2.340 | ||||
Breast | 18 | HG+ 0 | HG+ 2 | - | - |
HG- 18 | HG- 187 |