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Table 3 Relative risk (RR) of cancer in offspring according to maternal hyperemesis gravidarum (HG)- status for selected types of cancer combined and separately, with 95 % confidence intervals (95 % CI)

From: Hyperemesis gravidarum and risk of cancer in offspring, a Scandinavian registry-based nested case–control study

  N Cases Controls Crude RR (95 % CI) Adjusted RR* (95 % CI)
Total 14.805 HG+ 97 HG+ 818 1.18 (0.95-1.46) 1.19 (0.97-1.48)
HG- 14.708 HG- 146.891
Leukemia 5.114 HG+ 28 HG+ 280 0.99 (0.67-1.47) 1.00 (0.68-1.48)
HG-5.086 HG- 50.845
Central nervous 4.524 HG+ 29 HG+ 242 1.20 (0.81-1.78) 1.24 (0.84-1.83)
system HG- 4.495 HG- 45.026
Lymphoma 1.853 HG+ 15 HG+ 102 1.70 (0.98-2.96) 1.68 (0.97-2.92)
HG- 1.838 HG- 19.973
Testis 847 HG+ 4 HG+ 51 0.87 (0.31-2.43) 0.87 (0.31-2.43)
HG- 843 HG- 9.190
Nephroblastoma 441 HG+ 8 HG+ 48 1.97 (0.91-4.23) 2.01 (0.93-4.34)
HG- 433 HG- 4.850
Adrenal gland 417 HG+ 3 HG+ 28 1.12 (0.34-3.75) 1.14 (0.34-3.80)
HG- 414 HG- 4.567
Primary bone 394 HG+ 2 HG+ 15 1.40 (0.31-6.20) 1.38 (0.31-6.15)
HG-392 HG- 4.286
Retinoblastoma 345 HG+ 3 HG+ 36 0.97 (0.29-3.20) 0.97 (0.29-3.20)
HG- 342 HG- 3.725
Thyroid gland 343 HG+ 4 HG+ 21 2.11 (0.71-6.29) 2.21 (0.73-6.71)
  HG- 339 HG- 3.836
Ovary 296 HG+ 1 HG+ 20 0.50 (0.07-3.72) 0.48 (0.06-3.62)
HG- 295 HG- 3.193
Hepatoblastoma 213 HG+ 0 HG+ 13 - -
HG- 213 HG- 2.340
Breast 18 HG+ 0 HG+ 2 - -
HG- 18 HG- 187
  1. *Adjusted for maternal age and maternal country of birth