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Table 1 Somatic hotspot mutation frequencies for MC and MBOT

From: Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms

Carcinoma (n = 37)

Mutation Events

Frequency

KRAS

24

 

64.9

TP53

24

*

56.8

CDKN2A

8

*

18.9

PIK3CA

5

 

13.5

PTEN

2

*

2.7

BRAF

2

 

5.4

FGFR2

1

 

2.7

STK11

1

 

2.7

CTNNB1

2

 

5.4

SRC

1

 

2.7

SMAD4

1

 

2.7

Total Number Mutations

71

  

ERBB2 Amplification

14

§

37.8

Borderline Tumor (n = 26)

Mutation Events

Frequency

KRAS

24

 

92.3

TP53

3

 

11.5

CDKN2A

5

 

19.2

PIK3CA

4

 

15.4

PTEN

1

 

3.8

GNA11

1

 

3.8

ERBB2

1

 

3.8

Total Number Mutations

39

  

ERBB2 Amplification

3

§

11.5

Total # Mutations

110

  
  1. *Multiple cases with 2 mutation events. Number of mutated cases were used to establish frequency across cohort: TP53 (n = 21), CDKN2A (n = 7) and PTEN (n = 1)
  2. §Derived from Anglesio et al., 2013 [13]
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BMC Cancer

ISSN: 1471-2407

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