Skip to main content

Table 1 Somatic hotspot mutation frequencies for MC and MBOT

From: Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms

Carcinoma (n = 37) Mutation Events Frequency
KRAS 24   64.9
TP53 24 * 56.8
CDKN2A 8 * 18.9
PIK3CA 5   13.5
PTEN 2 * 2.7
BRAF 2   5.4
FGFR2 1   2.7
STK11 1   2.7
CTNNB1 2   5.4
SRC 1   2.7
SMAD4 1   2.7
Total Number Mutations 71   
ERBB2 Amplification 14 § 37.8
Borderline Tumor (n = 26) Mutation Events Frequency
KRAS 24   92.3
TP53 3   11.5
CDKN2A 5   19.2
PIK3CA 4   15.4
PTEN 1   3.8
GNA11 1   3.8
ERBB2 1   3.8
Total Number Mutations 39   
ERBB2 Amplification 3 § 11.5
Total # Mutations 110   
  1. *Multiple cases with 2 mutation events. Number of mutated cases were used to establish frequency across cohort: TP53 (n = 21), CDKN2A (n = 7) and PTEN (n = 1)
  2. §Derived from Anglesio et al., 2013 [13]