Table 1 Feasibility results

I. Patient recruitment & access

I.i Comorbidity & medication free

< 5 %

3.6 % (1/28 OEP)

100 %

I.ii Patient identification rate

>40 patient/year

>46 patients/year

100 %

II. Subject retention

>95 %

92.3 %

97.2 %

III. Baseline establishment

III.i Days between diagnosis & T1

≤9 days

9.1 days

99.9 %

III.ii Time-related testing constraints

<20 % missed

27 % missed

91 %

IV. Test performance & tolerability

IV.i Test performance

>95 % test completion

94.3 test completion

99.3 %

IV.ii Testing tolerance

<1 % AEs/< 10 % ACs

0.83 % AE / 5.1 % AC

100 % / 100 %

V. Potentially confounding medication use

N/A

T1: 15.4 % T2: 83.3 %