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Fig. 4 | BMC Cancer

Fig. 4

From: Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization

Fig. 4

EGFR and ERK1/2 phosphorylation following treatment of SCC61 cells with test compounds. a Averaged quantification of Western blots analyzing Y1068- or Y1173-phosphorylated EGFR following 1 h pre-treatment with compounds, vehicle, cetuximab, or erlotinib, followed by 45 min treatment with vehicle or EGF +/− EGF. Values shown are normalized to total EGFR. b Averaged quantification of Western blots analyzing T202/Y204-phosphorylated ERK1/2 following 1 h pre-treatment with compounds, vehicle, cetuximab, or erlotinib, followed by 45 min treatment with vehicle or EGF +/− EGF. Values shown are normalized to total ERK1/2. c Representative Western blots for quantified data shown in parts a and b

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