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Table 3 The optional cutoff value generated from self-collected samples for detection of CIN3+ in self-collected samples with methylation of PAX1, SOX1 and ZNF582 genes

From: Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm

  Cutoff Pointa Positive cases of CIN2- Positive cases of CIN3+ Sensitivity (95 % CI) Specificity (95 % CI)
(Total, N = 70) (Total, N = 66)
PAX1 0.0027 20 48 0.73 0.71
(28.6 %) (70.6 %) (0.60 to 0.83) (0.60 to 0.82)
SOX1 0.516 18 48 0.73 0.74
(25.7 %) (72.7 %) (0.60 to 0.83) (0.62 to 0.84)
ZNF582 0.0204 16 51 0.77 0.77
(22.9 %) (77.3 %) (0.65 to 0.87) (0.66 to 0.86
Any of SOX1, PAX1   28 57 0.86 0.60
(38.9 %) (86.3 %) (0.76 to 0.94) (0.48 to 0.72)
Any of SOX1, ZNF582   26 55 0.83 0.63
(36.1 %) (83.4 %) (0.72 to 0.91) (0.51 to 0.74)
Any of PAX1, ZNF582   28 59 0.89 0.60
(38.9 %) (89.4 %) (0.79 to 0.96) (0.48 to 0.72)
Any one of three   35 62 0.94 0.50
(50.0 %) (93.9 %) (0.85 to 0.98) (0.38 to 0.62)
Any two three   12 47 0.71 0.83
(17.1 %) (71.2 %) (0.59 to 0.82) (0.72 to 0.91)
  1. CIN2 (including normal, CIN 1 and CIN 2), CIN3+ including CIN3, CIS, SCC, ASC and AC), CI confident interval
  2. aThe optimal cutoff value of methylation index is identified in the self-collected group