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Table 3 The optional cutoff value generated from self-collected samples for detection of CIN3+ in self-collected samples with methylation of PAX1, SOX1 and ZNF582 genes

From: Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm

 

Cutoff Pointa

Positive cases of CIN2-

Positive cases of CIN3+

Sensitivity (95 % CI)

Specificity (95 % CI)

(Total, N = 70)

(Total, N = 66)

PAX1

0.0027

20

48

0.73

0.71

(28.6 %)

(70.6 %)

(0.60 to 0.83)

(0.60 to 0.82)

SOX1

0.516

18

48

0.73

0.74

(25.7 %)

(72.7 %)

(0.60 to 0.83)

(0.62 to 0.84)

ZNF582

0.0204

16

51

0.77

0.77

(22.9 %)

(77.3 %)

(0.65 to 0.87)

(0.66 to 0.86

Any of SOX1, PAX1

 

28

57

0.86

0.60

(38.9 %)

(86.3 %)

(0.76 to 0.94)

(0.48 to 0.72)

Any of SOX1, ZNF582

 

26

55

0.83

0.63

(36.1 %)

(83.4 %)

(0.72 to 0.91)

(0.51 to 0.74)

Any of PAX1, ZNF582

 

28

59

0.89

0.60

(38.9 %)

(89.4 %)

(0.79 to 0.96)

(0.48 to 0.72)

Any one of three

 

35

62

0.94

0.50

(50.0 %)

(93.9 %)

(0.85 to 0.98)

(0.38 to 0.62)

Any two three

 

12

47

0.71

0.83

(17.1 %)

(71.2 %)

(0.59 to 0.82)

(0.72 to 0.91)

  1. CIN2 (including normal, CIN 1 and CIN 2), CIN3+ including CIN3, CIS, SCC, ASC and AC), CI confident interval
  2. aThe optimal cutoff value of methylation index is identified in the self-collected group