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Table 2 Comparison the detection of CIN3+ between the physician-collected and self-collected samples using methylation of PAX1, SOX1 and ZNF582 genes

From: Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm

Physician-collected Self-collected
  Cutoff Pointa Positive case of CIN2- Positive case of CIN3+ Sensitivity (95 % CI) Specificity (95 % CI) Positive in CIN2- Positive in CIN3+ Sensitivity (95 % CI) Specificity (95 % CI) P b
(Total, N = 70) (Total, N = 66) (Total N = 70) (Total N = 66)
PAX 1 0.014 16 42 0.64 0.77 17 40 0.61 0.76 0.81
(22.86 %) (64.64 %) (0.51 to 0.75) (0.66 to 0.86) (24.3 %) (60.6 %) (0.48 to 0.72) (0.64 to 0.85)
SOX1 0.156 18 49 0.74 0.74 25 51 0.77 0.64 0.81
(25.71 %) (74.24 %) (0.62 to 0.84) (0.62 to 0.84) (35.7 %) (77.3 %) (0.65 to 0.87) (0.52 to 0.75)
ZNF582 0.214 12 40 0.61 0.83 9 42 0.64 0.87 0.81
(17.14 %) (60.61 %) (0.48 to 0.72) (0.72 to 0.91) (12.9 %) (63.6 %) (0.51 to 0.75) (0.77 to 0.94)
Any of SOX1, PAX1   25 53 0.80 0.64 32 53 0.80 0.54 1.00
(35.71 %) (80.3 %) (0.69 to 0.89) (0.52 to 0.75) (44.7 %) (80.3 %) (0.69 to 0.89) (0.42 to 0.66)
Any of SOX1, ZNF582   22 53 0.80 0.69 27 53 0.80 0.61 1.00
(31.4 %) (80.3 %) (0.69 to 0.89) (0.56 to 0.79) (38.6 %) (80.3 %) (0.69 to 0.89) (0.49 to 0.73)
Any of PAX1, ZNF582   23 48 0.73 0.67 20 48 0.73 0.71 1.00
(32.9 %) (72.7 %) (0.60 to 0.83) (0.55 to 0.78) (28.6 %) (72.7 %) (0.60 to 0.83) (0.59 to 0.82)
Any one of three   29 57 0.86 0.59 34 55 0.83 0.51 0.75
(41.4 %) (86.4 %) (0.76 to 0.94) (0.46 to 0.70) (48.6 %) (83.3 %) (0.72 to 0.91) (0.39 to 0.64)
Any two of three   12 40 0.71 0.83 11 44 0.67 0.84 0.52
(17.1 %) (60.6 %) (0.48 to 0.72) (0.72 to 0.91) (15.7 %) (66.7 %) (0.5 to 0.78) (0.74 to 0.92)
  1. CI confident interval
  2. aThe optimal cutoff value of methylation index is identified in the physician-collected group and testing in the self-collected group
  3. bPerformed a McNemar test for the comparison of proportions of CIN3+ using the cutoff value of physician-collected samples