Skip to main content

Table 2 Comparison the detection of CIN3+ between the physician-collected and self-collected samples using methylation of PAX1, SOX1 and ZNF582 genes

From: Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm

Physician-collected

Self-collected

 

Cutoff Pointa

Positive case of CIN2-

Positive case of CIN3+

Sensitivity (95 % CI)

Specificity (95 % CI)

Positive in CIN2-

Positive in CIN3+

Sensitivity (95 % CI)

Specificity (95 % CI)

P b

(Total, N = 70)

(Total, N = 66)

(Total N = 70)

(Total N = 66)

PAX 1

0.014

16

42

0.64

0.77

17

40

0.61

0.76

0.81

(22.86 %)

(64.64 %)

(0.51 to 0.75)

(0.66 to 0.86)

(24.3 %)

(60.6 %)

(0.48 to 0.72)

(0.64 to 0.85)

SOX1

0.156

18

49

0.74

0.74

25

51

0.77

0.64

0.81

(25.71 %)

(74.24 %)

(0.62 to 0.84)

(0.62 to 0.84)

(35.7 %)

(77.3 %)

(0.65 to 0.87)

(0.52 to 0.75)

ZNF582

0.214

12

40

0.61

0.83

9

42

0.64

0.87

0.81

(17.14 %)

(60.61 %)

(0.48 to 0.72)

(0.72 to 0.91)

(12.9 %)

(63.6 %)

(0.51 to 0.75)

(0.77 to 0.94)

Any of SOX1, PAX1

 

25

53

0.80

0.64

32

53

0.80

0.54

1.00

(35.71 %)

(80.3 %)

(0.69 to 0.89)

(0.52 to 0.75)

(44.7 %)

(80.3 %)

(0.69 to 0.89)

(0.42 to 0.66)

Any of SOX1, ZNF582

 

22

53

0.80

0.69

27

53

0.80

0.61

1.00

(31.4 %)

(80.3 %)

(0.69 to 0.89)

(0.56 to 0.79)

(38.6 %)

(80.3 %)

(0.69 to 0.89)

(0.49 to 0.73)

Any of PAX1, ZNF582

 

23

48

0.73

0.67

20

48

0.73

0.71

1.00

(32.9 %)

(72.7 %)

(0.60 to 0.83)

(0.55 to 0.78)

(28.6 %)

(72.7 %)

(0.60 to 0.83)

(0.59 to 0.82)

Any one of three

 

29

57

0.86

0.59

34

55

0.83

0.51

0.75

(41.4 %)

(86.4 %)

(0.76 to 0.94)

(0.46 to 0.70)

(48.6 %)

(83.3 %)

(0.72 to 0.91)

(0.39 to 0.64)

Any two of three

 

12

40

0.71

0.83

11

44

0.67

0.84

0.52

(17.1 %)

(60.6 %)

(0.48 to 0.72)

(0.72 to 0.91)

(15.7 %)

(66.7 %)

(0.5 to 0.78)

(0.74 to 0.92)

  1. CI confident interval
  2. aThe optimal cutoff value of methylation index is identified in the physician-collected group and testing in the self-collected group
  3. bPerformed a McNemar test for the comparison of proportions of CIN3+ using the cutoff value of physician-collected samples
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us