Fig. 1

DT320 induces complete regression of suppressed MDA-MB-235 GFP tumors. For the in vivo efficacy of DT320 in 500,000 MDA-MB-435-GFP cells were implanted together with SISgel in the flank of NCr nu/nu athymic mice. One week after inoculation, DT320 was administered i.p. at 45 mg/kg three times weekly for 3 weeks. In 6 of 8 flanks treated with DT320, suppressed tumor cell spots disappeared, while the tumor cell spots in the 6 flanks treated with gemcitabine (75 mg/kg, twice weekly) remained present. (For space considerations, the other two xenografts not responding to gemcitabine were not shown). Images are taken at 4 weeks after implantation. The difference in response was statistically significant at p = 0.0097 using Fisher’s Exact Test