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Table 1 Summary of demographic characteristics of HNCSS patients and acetyl- and butyrylcholinesterase activity in upper respiratory epithelium

From: Dysregulated cholinergic network as a novel biomarker of poor prognostic in patients with head and neck squamous cell carcinoma

   AChE activity (mU/mg protein) BChE activity (mU/mg protein)
Samples N ANCT Tumour P-value ANCT Tumour P-value
Total 57 5.416 ± 0.501 3.584 ± 0.633 0.002 6.350 ± 0.599 3.965 ± 0.423 <0.001
Gender        
Male 53 5.094 ± 0.473 3.525 ± 0.674 0.003 6.278 ± 0.638 3.952 ± 0.450 0.001
Female 4 9.680 ± 2.962 4.363 ± 1.395 0.273 5.730 ± 1.303 3.142 ± 0.843 0.068
Age        
<60 18 6.175 ± 0.929 4.553 ± 1.390 0.145 7.007 ± 1.311 4.572 ± 0.808 0.093
>60 39 5.066 ± 0.593 3.136 ± 0.669 0.005 5.891 ± 0.648 3.825 ± 0.495 0.002
Tobacco        
Non-smoker 5 4.978 ± 1.556 3.135 ± 1.820 0.225 3.891 ± 0.876 3.657 ± 0.922 0.893
Smoker 46 5.145 ± 0.510 3.721 ± 0.741 0.017 6.852 ± 0.716 3.872 ± 0.431 <0.001
Alcohol        
No 17 5.219 ± 0.621 3.524 ± 0.695 0.290 5.807 ± 1.034 4.701 ± 0.645 0.650
Yes 16 5.921 ± 0.822 3.737 ± 1.425 0.034 6.491 ± 0.745 3.746 ± 0.445 <0.001
Location        
Glottic 29 4.736 ± 0.663 3.467 ± 0.902 0.003 5.978 ± 0.794 3.612 ± 0.697 0.004
Supraglottic 21 5.200 ± 0.607 4.423 ± 1.201 0.017 7.593 ± 1.205 4.299 ± 0.603 0.007
Other 7 8.374 ± 1.699 2.699 ± 0.692 0.052 4.544 ± 0.530 4.362 ± 0.843 1.000
Differentiation        
Well 17 5.279 ± 0.828 4.057 ± 1.473 0.227 5.013 ± 0.806 3.771 ± 0.828 0.193
Moderate/Poor 32 5.123 ± 0.637 3.631 ± 0.807 0.030 7.684 ± 0.947 4.334 ± 0.622 0.002
Clinical Stage        
Stage I + II 19 4.660 ± 0.717 2.638 ± 0.714 0.059 6.118 ± 0.849 4.046 ± 0.858 0.058
Stage III + IV 36 5.319 ± 0.598 4.167 ± 0.921 0.033 6.568 ± 0.829 3.951 ± 0.504 0.002
Nodal Status        
N0 30 4.780 ± 0.530 3.231 ± 0.754 0.077 6.438 ± 0.857 3.624 ± 0.534 0.003
N+ 19 5.301 ± 0.943 3.432 ± 1.335 0.032 6.644 ± 1.006 4.878 ± 0.838 0.039
T Stage        
T1 4 4.707 ± 1.638 1.405 ± 0.670 0.068 4.456 ± 0.583 2.228 ± 0.367 0.068
T2 16 4.485 ± 0.790 2.893 ± 0.822 0.179 7.293 ± 1.302 4.265 ± 0.952 0.063
T3 24 5.727 ± 1.178 4.600 ± 1.562 0.382 6.522 ± 1.681 3.815 ± 0.559 0.110
T4 11 5.224 ± 0.692 4.019 ± 1.214 0.031 6.085 ± 0.853 4.331 ± 0.756 0.028