Fig. 1

Association of cell surface GRP78 with α2M* facilitated the invasion and metastasis of HCC. (a-b) Transwell analysis of the invasion of serum starved QGY-7703 and PLC cells treated with vehicle and α2M*. (c-d) Wound healing analysis of the migration of serum starved QGY-7703 and PLC cells treated with vehicle and α2M*. (e) Transwell analysis of the effect of antibody blocking on the invasion of serum starved QGY-7703 and PLC cells treated with vehicle and α2M*. (f-g) Quantitative analysis of the effect of antibody blocking on the invasion of serum starved QGY-7703 and PLC cells treated with vehicle and α2M*. (h) Cell adhesion analysis of the effect of antibody blocking on the binding ability to fibronectin in QGY-7703 cells. All these experiments were repeated for 3 times in triplicate. These data were presented as \( \overline{X} \pm \mathrm{S}\mathrm{D} \) and analyzed using student’s t-test and one-way ANOVA. The difference is regarded to be statistically significant when p < 0.05. *represented that the difference is statistically significant