Skip to main content

Table 2 Multivariate analysis of patients with osteosarcomas receiving neoadjuvant chemotherapy

From: Prognostic value of tumor suppressors in osteosarcoma before and after neoadjuvant chemotherapy

  A. Cox regression analysis of association between clinicopathologic variables and overall survival B. Binary logistic regression analysis of association between clinicopathologic variables and tumor-response status
Variablesa P-value HR 95 % CI P-value OR 95 % CI
Age 0.973     0.126    
<10 years 0.829 0.000 0.000 0.043 0.006 0.000 0.845
10–24 years 0.922 0.876 0.063 12.227 0.084 0.012 0.000 1.814
Gender 0.122 4.390 0.674 28.596 0.609 2.189 0.109 44.045
Location 0.972     0.601    
Tibia/ fibula/calcaneus 0.743 0.000 0.000 0.999 6.119E9 0.000
Femur 0.737 0.000 0.000 0.999 4.232E9 0.000
Humerus/ulna 0.719 0.000 0.000 0.999 5.229E10 0.000
Histological subtype 0.902     0.935    
Chondroblastic 0.986 0.139 0.000 0.999 8.367E8 0.000
Fibroblastic 0.922 22186 0.000 0.999 0.000 0.000
Osteoblastic 0.932 6308 0.000 0.514 5.300 0.036 789.165
RX P16 negative (n = 39) 0.003 0.067 0.011 0.397 0.004 74.076 3.875 1415.946
RX P53 negative (n = 44) 0.315 0.515 0.141 1.879 0.159 4.786 0.541 42.368
RX PTEN negative (n = 22) 0.166 5.342 0.498 57.310 0.999 2.169E9 0.000
RX Maspin negative (n = 33) 0.409 0.482 0.085 2.725 0.192 4.384 0.477 40.278
RX Ki67 negative (n = 25) 0.069 0.157 0.021 1.157 0.999 1.934E9 0.000
RX BMI1 negative (n = 28) 0.353 3.624 0.239 54.951 1.000 0.000 0.000
  1. In the upper section, the multivariate analysis including P16 is shown. In the lower section, statistical parameters of biomarker expression of separate multivariate analyses (including the same clinicopathologic factors from the upper section) are shown
  2. RX resection, HR hazard ratio, OR Odds ratio, ∞ infinity
  3. aCoding of variables was a follows: age: 1 (<10 year), 2 (10–24 years) and 3 (>24 year). Gender: 1 (female) and 2 (male). Location: 1 (tibia/ fibula/ calcaneus), 2 (femur), 3 (humerus/ ulna) and 4 (axial sites). Histological subtype: 1 (chondroblastic) 2 (fibroblastic), 3 (osteoblastic) and 4 (telangiectatic)