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Table 2 Multivariate analysis of patients with osteosarcomas receiving neoadjuvant chemotherapy

From: Prognostic value of tumor suppressors in osteosarcoma before and after neoadjuvant chemotherapy

 

A. Cox regression analysis of association between clinicopathologic variables and overall survival

B. Binary logistic regression analysis of association between clinicopathologic variables and tumor-response status

Variablesa

P-value

HR

95 % CI

P-value

OR

95 % CI

Age

0.973

   

0.126

   

<10 years

0.829

0.000

0.000

∞

0.043

0.006

0.000

0.845

10–24 years

0.922

0.876

0.063

12.227

0.084

0.012

0.000

1.814

Gender

0.122

4.390

0.674

28.596

0.609

2.189

0.109

44.045

Location

0.972

   

0.601

   

Tibia/ fibula/calcaneus

0.743

0.000

0.000

∞

0.999

6.119E9

0.000

∞

Femur

0.737

0.000

0.000

∞

0.999

4.232E9

0.000

∞

Humerus/ulna

0.719

0.000

0.000

∞

0.999

5.229E10

0.000

∞

Histological subtype

0.902

   

0.935

   

Chondroblastic

0.986

0.139

0.000

∞

0.999

8.367E8

0.000

∞

Fibroblastic

0.922

22186

0.000

∞

0.999

0.000

0.000

∞

Osteoblastic

0.932

6308

0.000

∞

0.514

5.300

0.036

789.165

RX P16 negative (n = 39)

0.003

0.067

0.011

0.397

0.004

74.076

3.875

1415.946

RX P53 negative (n = 44)

0.315

0.515

0.141

1.879

0.159

4.786

0.541

42.368

RX PTEN negative (n = 22)

0.166

5.342

0.498

57.310

0.999

2.169E9

0.000

∞

RX Maspin negative (n = 33)

0.409

0.482

0.085

2.725

0.192

4.384

0.477

40.278

RX Ki67 negative (n = 25)

0.069

0.157

0.021

1.157

0.999

1.934E9

0.000

∞

RX BMI1 negative (n = 28)

0.353

3.624

0.239

54.951

1.000

0.000

0.000

∞

  1. In the upper section, the multivariate analysis including P16 is shown. In the lower section, statistical parameters of biomarker expression of separate multivariate analyses (including the same clinicopathologic factors from the upper section) are shown
  2. RX resection, HR hazard ratio, OR Odds ratio, ∞ infinity
  3. aCoding of variables was a follows: age: 1 (<10 year), 2 (10–24 years) and 3 (>24 year). Gender: 1 (female) and 2 (male). Location: 1 (tibia/ fibula/ calcaneus), 2 (femur), 3 (humerus/ ulna) and 4 (axial sites). Histological subtype: 1 (chondroblastic) 2 (fibroblastic), 3 (osteoblastic) and 4 (telangiectatic)