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Table 1 IC50 values (μM) for adherent and sphere cells exposed to various anti-cancer agents

From: Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner

Cell line

Doxorubicin

Paclitaxel

α-TOS

MitoVES

 

ADH

SPH

ADH

SPH

ADH

SPH

ADH

SPH

NeuTL

0.45 ± 0.07a

1.44 ± 0.17

0.26 ± 0.06

>10

53 ± 4.5

58 ± 6.3

1.9 ± 0.31

1.1 ± 0.25

MCF7

n.d.b

n.d.

n.d.

n.d.

24.8 ± 2.2

28.6 ± 1.9

4.52 ± 0.29

1.2 ± 0.25

MCF7 SDHClow

n.d.

n.d.

n.d.

n.d.

n.d.

n.d.

n.d.

8.2 ± 1.3

  1. aIC50 values were calculated form the killing curves of the various adherent and sphere cell cultures exposed to the agents for 24 h. The killing curves were constructed using the MTT assay
  2. bn.d.: not determined
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BMC Cancer

ISSN: 1471-2407

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