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Fig. 5 | BMC Cancer

Fig. 5

From: Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner

Fig. 5

MitoVES suppresses tumour progression. NeuTL adherent (A) and sphere cells (B) were grafted s.c. in FVB/N c-neu mice (106 cells per animal) and tumour volume assessed in control and MitoVES-treated animals using USI. The images on the right are representative USI scans of tumours taken on the given days (indicated by arrows in the graph on the left), the images on the right also show representative tumours excised from mice at the end of the experiment. Tumours derived from adherent (C) and sphere NeuTL cells (D) were paraffin-embedded, sectioned and probed by IHC for cleaved caspase-3. Tumour tissue was shredded and oxygen consumption evaluated using oxygraph. The respiration via mitochondrial complexes was assessed and calculated (E, F). Data are mean values ± S.D. (n = 3). The symbol ‘*’ in panels A and B indicates statistically significant differences in the volume of control and MitoVES-treated tumours with p < 0.05. Images in panels C and D are representative of three independent experiments. The symbol ‘*’ in panel F and G indicates statistically significant differences in the respiration levels of control and MitoVES-treated tumours with p < 0.05

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