BMC Cancer

Table 3 Relationship of status of EGFR in ESCC with the clinicopathological parameters

From: The prognostic value of EGFR overexpression and amplification in Esophageal squamous cell Carcinoma

		EGFR-IHC result							EGFR-FISH result
		System 1				System 4			FISH Positive			Amplification
	N	L	M	H	P	L	H	P	No	Yes	P	No	Yes	P
Gender
Male	80	42	32	6	0.724	74	6	0.509	52	28	0.022	74	6	0.861
Female	16	7	7	2		14	2		15	1		15	1
Age
<60	34	24	8	2	0.017	22	12	0.422	22	12	0.422	32	2	0.694
>60	62	25	31	6		45	17		45	17		57	5
Tumor site
Upper	1	0	1	0	0.181	1	0	0.607	1	0	0.313	1	0	0.413
Middle	33	12	17	4		29	4		20	13		29	4
Lower	62	37	21	4		58	4		46	16		59	3
T-stage
T1	5	2	3	0	0.889	5	0	0.499	3	2	0.552	5	0	0.602
T2	24	13	9	2		23	1		15	9		23	1
T3	67	34	27	6		60	7		49	18		61	6
Vaso invasion
No	77	34	35	8	0.020	69	8	0.142	54	23	0.884	70	7	0.172
Yes	19	15	4	0		19	0		13	6		19	0
Nerve invasion
No	62	34	24	4	0.497	59	3	0.094	44	18	0.735	59	3	0.212
Yes	34	15	15	4		29	5		23	11		30	4
LN metastases
No	52	29	22	1	0.046	51	1	0.013	39	13	0.227	51	1	0.028
Yes	44	20	17	7		37	7		28	16		38	6
Necrosis
No	38	21	16	1	0.258	36	2	0.378	27	11	0.828	37	1	0.155
Yes	58	28	23	7		52	6		40	18		52	6
Mitoses (/10HPF)
≤20	29	12	15	2	0.645	27	2	0.307	18	11	0.06	27	2	0.768
20~50	37	20	13	4		32	5		31	6		35	2
≥50	30	17	11	2		29	1		18	12		27	3
Tumour differentiation
G2	61	33	26	2	0.061	43	18	0.844	43	18	0.844	57	4	0.715
G3	35	16	13	6		24	11		24	11		32	3

System 1and System 4, EGFR-IHC scoring system 1 and 4
L, low level of EGFR expression; M, intermediate level; H, high level
FISH positive , EGFR gene amplification or high polysomy

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ISSN: 1471-2407

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