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Table 2 Correlation between EGFR protein expression and gene variation

From: The prognostic value of EGFR overexpression and amplification in Esophageal squamous cell Carcinoma

 

EGFR-FISH result

EGFR-IHC

FISH positive

Amplification

 

No

Yes

P

No

Yes

P

System 1

  

0.034

  

0.001

L

39

10

 

9

0

 

M

25

14

 

37

2

 

H

3

5

 

3

5

 

System 2

  

0.036

  

0.015

L

34

8

 

42

0

 

H

31

21

 

47

7

 

System 3

  

0.120

  

0.006

L

37

11

 

48

0

 

H

30

18

 

41

7

 

System 4

  

0.038

  

0.001

L

64

24

 

86

2

 

H

3

5

 

3

5

 

System 5

  

0.674

  

0.299

L

9

3

 

12

0

 

H

58

26

 

77

7

 

System 6

  

0.175

  

0.027

L

11

3

 

14

0

 

M

26

7

 

33

0

 

H

30

19

 

42

7

 

Total

67

29

 

89

7

 
  1. System 1–6, EGFR-IHC scoring system 1–6
  2. L, low level of EGFR expression; M, intermediate level; H, high level
  3. FISH positive, EGFR gene amplification or high polysomy
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