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Table 1 Comparison of EGFR-IHC results of 6 scoring systems

From: The prognostic value of EGFR overexpression and amplification in Esophageal squamous cell Carcinoma

Pairs

Levels

Number

P

Kappa

System 1 vs. System 6

(L/M/H) vs. (L/M/H)

(49/39/8) vs. (14/33/49)

0.001

0.037

System 2 vs. System 3

(L/H) vs. (L/H)

(42/54) vs. (48/48)

0.031

0.875

System 2 vs. System 4

(L/H) vs. (L/H)

(42/54) vs. (88/8)

0.001

0.132

System 2 vs. System 5

(L/H) vs. (L/H)

(42/54) vs. (12/84)

0.001

0.31

System 3 vs. System 4

(L/H) vs. (L/H)

(48/48) vs. (88/8)

0.001

0.167

System 3 vs. System 5

(L/H) vs. (L/H)

(48/48) vs. (12/84)

0.001

0.25

System 4 vs. System 5

(L/H) vs. (L/H)

(88/8) vs. (12/84)

0.001

0.026

  1. The McNemar Test, P < 0.05 was considered statistically significant difference
  2. Kappa > =0.75 was regarded as better concordance, Kappa < 0.4 indicated a poor concordance
  3. System 1–6, EGFR-IHC scoring system 1 to 6
  4. L, low level of EGFR expression; M, intermediate level; H, high level
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BMC Cancer

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